Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Mouse (Murine) Antikörper:
anti-Rat (Rattus) Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal HDAC8 Primary Antibody für IHC - ABIN966268
Lee, Rezai-Zadeh, Seto: Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. in Molecular and cellular biology 2003
Human Polyclonal HDAC8 Primary Antibody für IP, IHC - ABIN223303
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
MSC (zeige MSC Antikörper) from MPN (zeige PRSS27 Antikörper) have higher expression of HDAC8 than normal ones, and the inhibition of HDAC8 expression by its specific inhibitor decreases the capacity of the stroma to support hematopoietic cells from MPN (zeige PRSS27 Antikörper) patients, suggesting that HDAC8 may be a potential therapeutic target in this setting.
This study for the first time demonstrated that HDAC8 activity determines susceptibility to cell cycle arrest induced by Anthrax Lethal Toxin, through regulating the PI3K (zeige PIK3CA Antikörper)-PTEN-AKT (zeige AKT1 Antikörper) signaling axis.
AHR (zeige AHR Antikörper) regulated cell proliferation and tumorigenesis by directly targeting and activating HDAC8 expression in hepatocellular carcinoma cells.
The Epac (zeige RAPGEF3 Antikörper)-Rap1 (zeige RABGEF1 Antikörper)-Akt (zeige AKT1 Antikörper) pathway mediates cAMP signaling-induced inhibition of JNK (zeige MAPK8 Antikörper)-dependent HDAC8 degradation, and the resulting HDAC8 increase augments cisplatin-induced apoptosis by repressing TIPRL (zeige TIPRL Antikörper) expression in H1299 lung cancer cells.
The X-ray crystal structure of HDAC8 complexed with inhibitor confirms the formation of a unique subpocket in HDAC8.
These data provide support for the hypothesis that HDAC8 may undergo metal switching in vivo that, in turn, may regulate its activity. However, future studies are needed to explore the identity of the metal ion bound to HDAC8 in cells under varied conditions
The study reports the crystal structure of the HDAC8-trapoxin A complex at 1.24 A resolution, revealing that the ketone moiety of l-Aoe undergoes nucleophilic attack to form a zinc-bound tetrahedral gem (zeige GEM Antikörper)-diolate that mimics the tetrahedral intermediate and its flanking transition states in catalysis.
The findings suggest that miR (zeige MLXIP Antikörper)-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2 (zeige HDAC2 Antikörper)/8 and promoting histone H3 (zeige HIST3H3 Antikörper) acetylation.
7-amino-4-methylcoumarin did not affect acetyllysine preference in a multiply acetylated substrate. In contrast, AMC significantly enhanced KDAC6 substrate affinity, greatly reduced Sirt1 (zeige SIRT1 Antikörper) activity, eliminated the substrate sequence specificity of KDAC4, and had no consistent effect with KDAC8 substrates.
Enzymological, biophysical, and structural studies of Cornelia de Lange Syndrome HDAC8 protein mutants have yielded critical insight on compromised catalysis in vitro. Most CdLS (zeige NIPBL Antikörper) HDAC8 mutations trigger structural changes that directly or indirectly impact substrate binding and catalysis.
HDAC8 regulates neural differentiation by exerting control of embryoid body formation.
Results indicate that HDAC8 functions to modulate p53 (zeige TP53 Antikörper) activity to ensure long-term hematopoietic stem cells (LT-HSCs) maintenance and cell survival under stress.
this study demonstrates a novel role of HDAC8 in LeTx immunotoxicity and regulation of pro-IL-1beta (zeige IL1B Antikörper) production likely through eRNAs.
findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis
Data reveal a role for miR-21-3p in regulating HDAC8 expression and Akt/Gsk3beta pathway in cardiac hypertrophy.
histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo
HDAC8 and Sirt1 (zeige SIRT1 Antikörper) were also demonstrated to interact directly with ERRalpha (zeige ESRRA Antikörper) in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha (zeige ESRRA Antikörper) in vitro.
Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and deletion of Hdac8 in cranial neural crest cells and Hdac8 specifically represses the aberrant expression of homeobox (zeige PRRX1 Antikörper) transcription factors such as Otx2 (zeige OTX2 Antikörper) and Lhx1 (zeige LHX1 Antikörper)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
histone deacetylase 8
, histone deacetylase-like 1