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Cow (Bovine) Polyclonal FBP1 Primary Antibody für IHC, WB - ABIN2776794
Yáñez, Bertinat, Spichiger, Carcamo, de Los Angeles García, Concha, Nualart, Slebe: Novel expression of liver FBPase in Langerhans islets of human and rat pancreas. in Journal of cellular physiology 2005
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Human Polyclonal FBP1 Primary Antibody für IHC, IHC (p) - ABIN4310717
Li, Qiu, Lee, Walton, Ochocki, Mathew, Mancuso, Gade, Keith, Nissim, Simon: Fructose-1,6-bisphosphatase opposes renal carcinoma progression. in Nature 2014
Study identified for the first time that HNF4alpha (zeige HNF4A Antikörper) and C/EBPalpha (zeige CEBPA Antikörper) are important transcriptional regulators for FBP1 expression in human hepatoma HepG2 cells.
FBP1 mutation was associated with fructose-1,6-bisphosphatase deficiency
Results identified FBP1 as a promising acute liver failure (ALF (zeige GTF2A1L Antikörper)) biomarker among energy metabolism-related proteins. It may serve as a short-term prognosis indicator for ALF (zeige GTF2A1L Antikörper), with higher serum level of FBP1 correlated with higher ALF (zeige GTF2A1L Antikörper)-related mortality in human studies.
Here, the first crystal structure of human liver FBPase in the R-state conformation is presented, determined at a resolution of 2.2 A in a tetragonal setting that exhibits an unusual arrangement of noncrystallographic symmetry (NCS) elements.
Studied association of fructose 1,6-bisphosphatase 1 (FBP1) expression with fluorine 18 ((18)F) fluorodeoxyglucose (FDG (zeige SMUG1 Antikörper)) accumulation in patients with hepatocellular carcinoma. Found that in patients with HCC (zeige FAM126A Antikörper), both 18F FDG (zeige SMUG1 Antikörper) accumulation and tumor grade (from differentiated to undifferentiated) were inversely correlated with the expression of FBP1.
These findings indicate that FBP1 appears to be a tumor suppressor in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)). Strategies to restore the levels and activities of FBP1 might be developed to treat patients with HCC (zeige FAM126A Antikörper).
FBP1 underexpression is associated with Tumor Progression in Hepatocellular Carcinoma.
fructose-1,6-bisphosphatase 1 facilitated co-action between Bcl-2 (zeige BCL2 Antikörper) and Beclin 1 (zeige BECN1 Antikörper), which may be important in the mechanism of fructose-1,6-bisphosphatase 1-mediated mitophagy inhibition. In summary, loss of mitophagy by fructose-1,6-bisphosphatase 1-mediated repression promotes apoptosis in breast cancer
Downregulation of FBP1 promotes gastric cancer metastasis by facilitating EMT (zeige ITK Antikörper) and acts as a potential prognostic factor and therapeutic target in gastric cancer.
we show that EV71 viral proteinase 2A is capable of cleaving far upstream element-binding protein 1 (zeige FUBP1 Antikörper) (FBP1), a positive internal ribosome entry sitet rans-acting factor that directly binds to the EV71 5' UTR (zeige UTS2R Antikörper) linker region to promote viral IRES-driven translation
The results suggested that the FBP1 (zeige FBP2 Antikörper) signaling pathway may serve an important role in normal follicle growth and hyperandrogenisminduced abnormal development, which may be associated with abnormal glucose metabolism induced by high concentrations of testosterone.
The Identification of FBPase interacting partners with mass spectrometry reveals a set of nuclear proteins involved in cell cycle regulation, mRNA processing and in stabilization of genomic DNA structure.
FBPase plays an important role in regulating glucose sensing and insulin (zeige INS Antikörper) secretion of beta-cells and serves a promising target for diabetes treatment.
Data show that NF-kappaB (zeige NFKB1 Antikörper) functions downstream of Ras to promote epigenetic downregulation of FBP1 (zeige FBP2 Antikörper).
Directed mutations, kinetics, and structure determinations link the central cavity of FBP to AMP (zeige TMPRSS5 Antikörper)/fructose 2,6-bisphosphate synergism.
The AMP (zeige TMPRSS5 Antikörper)/Mg(2 (zeige MCOLN1 Antikörper)+) and AMP (zeige TMPRSS5 Antikörper)/Zn(2+) complexes of Asp (zeige ASIP Antikörper)(10) FBPase are in intermediate quaternary conformations.
each subunit in the wild-type tetramer can independently achieve maximum velocity when activated by Mg(2 (zeige MCOLN1 Antikörper)+); findings are fully consistent with a mechanism of cooperativity that arises from within a single subunit of fructose-1,6-bisphosphatase.
Ca2 (zeige CA2 Antikörper)+ appears to be a strong inhibitor of muscle FBPase (fructose 1,6-diphosphatase).
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
, FBPase 1
, fructose-bisphosphatase 1
, growth-inhibiting protein 17
, D-fructose-1,6-bisphosphate 1-phosphohydrolase 3
, FBPase brain isoform
, FBPase liver
, fructose-1,6-bisphosphatase 1
, fructose-1,6-bisphosphatase isozyme 3
, fructose 1,6-bisphosphatase
, Fructose-16- biphosphatase
, fructose-1,6- biphosphatase 1
, fructose-1,6-bisphosphatase 1, like
, fructose-bisphosphatase 1 S homeolog