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anti-Mouse (Murine) NUMB Antikörper:
anti-Human NUMB Antikörper:
anti-Rat (Rattus) NUMB Antikörper:
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Polyclonal NUMB Primary Antibody für WB - ABIN540356
Santolini, Puri, Salcini, Gagliani, Pelicci, Tacchetti, Di Fiore: Numb is an endocytic protein. in The Journal of cell biology 2001
Show all 3 Pubmed References
Chicken Polyclonal NUMB Primary Antibody für ICC, IF - ABIN152992
Lenihan, Saha, Heimer-McGinn, Cryan, Feng, Young: Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. in Molecular neurobiology 2016
Human Polyclonal NUMB Primary Antibody für ICC, IF - ABIN257778
Zhong, Feder, Jiang, Jan, Jan: Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. in Neuron 1996
Human Polyclonal NUMB Primary Antibody für IF (p), IHC (p) - ABIN744428
Mah, Soloff, Hedrick, Mariani: Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. in Stem cell reports 2015
Data suggest that Numb acts as a Notch (zeige NOTCH1 Antikörper) antagonist by controlling intracellular destination and stability of the Notch ligand (zeige JAG2 Antikörper) Delta-like (zeige DLK1 Antikörper) 4 (DLL4 (zeige DLL4 Antikörper)) through a post-endocytic sorting process; Numb negatively controls DLL4 (zeige DLL4 Antikörper) plasma membrane recycling through well-documented recycling regulator protein AP1 (zeige JUN Antikörper).
NUMB is necessary for establishing polarity in coelomic epithelium cells.
investigations revealed that NUMB and NUMBL (zeige NUMBL Antikörper) interacted with small GTPase (zeige RACGAP1 Antikörper) Rab7 (zeige RAB7A Antikörper) to transition ERBB2 (zeige ERBB2 Antikörper) from early to late endosome for degradation.
These findings highlight the importance of Numb and Numbl (zeige NUMBL Antikörper) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis
RBM4 (zeige RBM4 Antikörper) depletion reduced the expression of the proneural gene Mash1 (zeige ASCL1 Antikörper), and such reduction was reversed by an RBM4 (zeige RBM4 Antikörper)-induced Numb isoform containing exon 3 but lacking exon 9. RBM4 (zeige RBM4 Antikörper) was also essential for neurite outgrowth from cortical neurons in vitro. Neurite outgrowth defects of RBM4 (zeige RBM4 Antikörper)-depleted neurons were rescued by RBM4 (zeige RBM4 Antikörper)-induced exon 9-lacking Numb isoforms. RBM4 (zeige RBM4 Antikörper) modulates exon selection of Numb.
role in the mediation of TCR degradation
miR (zeige MLXIP Antikörper)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (zeige NOTCH1 Antikörper) to separate stem and non-stem cell fates robustly.
Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (zeige TLR4 Antikörper).
Loss of Numb induces a p53 (zeige TP53 Antikörper)-dependent senescence following skeletal muscle injury.
Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (zeige GRM1 Antikörper).
In the present study, we identified that the adaptor protein Numb, which is demonstrated to be a novel binding partner of NEDD4-1 (zeige NEDD4 Antikörper), plays important roles in controlling PTEN ubiquitination through regulating NEDD4-1 (zeige NEDD4 Antikörper) activity and the association between PTEN and NEDD4-1 (zeige NEDD4 Antikörper).
Numb expression is not associated with favorable prognosis in small cell lung cancer.
Data suggest that over-expression of NUMB has anti-cancer effects to prostatic cancer cells; these studies included experiments both in vitro and in vivo (xenograft experiments in nude mice).
Using patient-derived xenografts, the study shows that expansion of the cancer stem cells pool, due to altered self-renewing divisions, is also a feature of Numb-deficient human breast cancers .
Numb binds to another docking regulator, Mon1b, and is required for the recruitment of cytosolic Mon1b to the early endosomes membrane.
Low NUMB expression is associated with pancreatic cancer.
Together, our findings revealed a novel function of Numb and its likely mechanism in regulation of autophagy events.
investigations revealed that NUMB and NUMBL (zeige NUMBL Antikörper) interacted with small GTPase (zeige RACGAP1 Antikörper) Rab7 (zeige RAB7B Antikörper) to transition ERBB2 (zeige ERBB2 Antikörper) from early to late endosome for degradation.
Our evidence supports a mechanism by which Numb AS is regulated in response to oncogenic signaling pathways, and contributes to activation of downstream pathways to promote tumorigenesis.
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
protein numb homolog
, numb gene homolog