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anti-Human Desmoglein 2 Antikörper:
anti-Mouse (Murine) Desmoglein 2 Antikörper:
anti-Rat (Rattus) Desmoglein 2 Antikörper:
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Human Monoclonal Desmoglein 2 Primary Antibody für IHC (fro), IP - ABIN2473331
: [The 5th consensus conference on intensive care and emergency medicine. Diagnosis of nosocomial pneumopathies in intensive care. 13 October 1989, Bicêtre]. in La Revue du praticien 1990
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Human Monoclonal Desmoglein 2 Primary Antibody für IHC (fro), WB - ABIN2191994
Wahl, Sacco, McGranahan-Sadler, Sauppé, Wheelock, Johnson: Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. in Journal of cell science 1996
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Human Monoclonal Desmoglein 2 Primary Antibody für ICC, IF - ABIN1169682
Keim, Johnson, Wheelock, Wahl: Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2. in Hybridoma (2005) 2008
Human Monoclonal Desmoglein 2 Primary Antibody für EIA, IHC (fro) - ABIN112136
Franke, Nuber, Schmidt, Schäfer: Desmosomes--dual junctional principles of intra- and supracellular order in epithelial differentiation and tissue formation. in Verhandlungen der Deutschen Gesellschaft für Pathologie 1995
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Cow (Bovine) Polyclonal Desmoglein 2 Primary Antibody für IHC, WB - ABIN2782147
Cirillo, Lanza, De Rosa, Cammarota, La Gatta, Gombos, Lanza: The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. in Journal of cellular biochemistry 2008
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Human Polyclonal Desmoglein 2 Primary Antibody für ICC, IF - ABIN4305012
Asplund, Gry Björklund, Sundquist, Strömberg, Edlund, Ostman, Nilsson, Pontén, Lundeberg: Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma. in The British journal of dermatology 2008
DSG2 as a key regulator of vasculogenic mimicry (VM) activity in human melanoma and suggest this molecule might be therapeutically targeted to reduce tumor blood supply and metastatic spread.
Data suggest that Dsg2 stimulates cell growth and migration by positively regulating EGFR (zeige EGFR Antikörper) level and signaling through a c-Src (zeige SRC Antikörper) and Cav1 (zeige CAV1 Antikörper)-dependent mechanism using lipid rafts as signal modulatory platforms.
identified DSG2 expression in distinct progenitor cell subpopulations and show that, independent from its classical functi (zeige HBA1 Antikörper)on as a component of desmosomes, this cadherin also plays a critical role in the vasculature
Data show that fetal pMSCs (mesenchymal stromal cells) expressing the highest levels of desmoglein 2, desmocollin 3 (zeige DSC2 Antikörper) and plakophilin 2 (zeige PKP2 Antikörper), followed by maternal pMSCs, while bmMSCs expressed the lowest levels.
Expression of the desmosomal protein Desmoglein-2 was reduced in pediatric dilated cardiomyopathy pediatric patients.
This study defines a mechanism by which Dsg2 expression in cancer cells can modulate the tumor microenvironment, a step critical for tumor progression.
Silencing of Dsg2 but not Dsc2 (zeige DSC2 Antikörper) resulted in loss of cell cohesion and enhanced migration, and invasion of pancreatic adenocarcinoma cells.
The homozygous desmoglein 2 variant c.1003A;G co-segregated with Arrhythmogenic right ventricular cardiomyopathy, indicating autosomal recessive inheritance and complete penetrance.
these data suggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane. Modulation of the palmitoylation status of desmosomal cadherins can affect desmosome dynamics.
Both Dsg2 mRNA and protein were highly expressed in non-small cell lung cancer (NSCLC) tissues and associated with NSCLC size, but not with overall survival of patients.
generated a Dsg2 loss-of-function strain (Dsg2 (lo/lo)) and observed that, in response to reduced levels of Dsg2: (i) CD31 (zeige PECAM1 Antikörper)(+) endothelial cells in the pancreas are hypertrophic and exhibit altered morphology, (ii) bone marrow-derived endothelial colony formation is impaired, (iii) ex vivo vascular sprouting from aortic rings is reduced, and (iv) vessel formation in vitro and in vivo is attenuated
Data suggest that loss of desmoglein 2 (Dsg2) compromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other desmosome-related arrhythmogenic cardiomyopathy (AC).
Dsg2 modulates Gli1 (zeige GLI1 Antikörper) expression. Dsg2-mediated hyperproliferation, MEK (zeige MDK Antikörper)/Erk1/2 activation, and accelerated squamous tumor development are enhanced on the Ptc1 (zeige PTCH1 Antikörper)+/lacZ (zeige GLB1 Antikörper) background.
a novel pathway of CSTA (zeige CSTA Antikörper) regulation involving Dsg2
Data demonstrate that desmoglein-2 plays a critical role in cardiomyocyte cohesion and function.
Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 (zeige DSC2 Antikörper) play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR (zeige EGFR Antikörper) signaling.
Dsg2 compensates for Dsg3 (zeige DSG3 Antikörper) depletion with regard to cell cohesion, but does not regulate p38 MAPK (zeige MAPK14 Antikörper) signaling.
In vivo interaction between Dsg2 and Na(V)1.5 provides a molecular pathway for the observed electrical disturbances during the early arrhythmogenic right ventricular cardiomyopathy.
Mutant desmoglein 2 cannot support the increased requirements placed on intercalated disc adhesion during postnatal heart development. This induces cardiomyocyte death, aseptic inflammation and fibrotic replacement.
ventricular arrhythmias that has been linked to mutations in desmosomal proteins including desmoglein 2
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
, Dsg alpha
, desmocollin a
, cadherin family member 5