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anti-Human ACTN1 Antikörper:
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Human Monoclonal ACTN1 Primary Antibody für ELISA, WB - ABIN559761
Quick, Skalli: Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. in Experimental cell research 2010
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Human Monoclonal ACTN1 Primary Antibody für ICC, IF - ABIN4279827
Shen, Soibam, Benham, Xu, Chopra, Peng, Yu, Bao, Liang, Azares, Liu, Gunaratne, Mercola, Cooney, Schwartz, Liu: miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification. in Proceedings of the National Academy of Sciences of the United States of America 2016
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Human Polyclonal ACTN1 Primary Antibody für IHC (p), IHC - ABIN442543
Hosseinibarkooie, Peters, Torres-Benito, Rastetter, Hupperich, Hoffmann, Mendoza-Ferreira, Kaczmarek, Janzen, Milbradt, Lamkemeyer, Rigo, Bennett, Guschlbauer, Büschges, Hammerschmidt, Riessland, Kye et al.: The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype. ... in American journal of human genetics 2016
Dog (Canine) Polyclonal ACTN1 Primary Antibody für IHC, IHC (p) - ABIN4279828
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Human Monoclonal ACTN1 Primary Antibody für IF, IHC - ABIN2715972
Shuliang, Lei, Guangwu, Changjie: Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells. in Oncology research 2014
these results indicate that increased alpha-actinin-1 expression destabilizes E-cadherin (zeige CDH1 Antikörper)-based adhesions, which is likely to promote the migratory potential of breast cancer cells. Furthermore, our results identify a-actinin-1 as a candidate prognostic biomarker in basal-like breast cancer.
These results demonstrate that both actinin-1 and actinin-4 (zeige ACTN4 Antikörper) participate in the assembly of F-actin at invadopodia. Additionally, actinin-4 (zeige ACTN4 Antikörper) may have a selective advantage in accelerating invadopodia-mediated invasion of carcinoma cells.
provide a structural model of regulation of the actin crosslinking activity of alpha-actinin-1 where calcium induced structural stabilisation causes fastening of the juxtaposed actin binding domain, leading to impaired capacity to crosslink actin
our 11 patients with macrothrombocytopenia related to ACTN1 mutation are characterized by an isolated autosomal dominant mild thrombocytopenia, with low bleeding tendency.
Calcium modulates calmodulin-ACTN1 interaction with and agonist-dependent internalization of the adenosine A2A receptor (zeige ADORA2A Antikörper).
Actinin-1 binds to the C-terminus of A2B adenosine receptor (zeige ADORA2B Antikörper) (A2BAR (zeige ADORA2B Antikörper)) and enhances A2BAR (zeige ADORA2B Antikörper) cell-surface expression
This suggests that a precise dosage of PC2 (zeige KRT6B Antikörper) is necessary for an adequate mechanosensitive alpha-actinin recruitment at junctions.
The present study identified a de novo mutation in ACTA1 (zeige ACTA1 Antikörper) (c.350A>G; p.Asn117Ser) in a Chinese patient using targetcapture sequencing of a panel containing 125 known causal genes for inherited muscle diseases.
Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and that fission factors such as actin filaments target productive oligomerization to fission sites.
Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy.
The data suggested that Daam1 (zeige DAAM1 Antikörper) affected actin assembly during oocyte meiotic division via the regulation of fascin (zeige FSCN1 Antikörper) expression.
Interactions with phosphatidylinositol 4,5-bisphosphate decrease the actin polymerizing activity of Ig domain 3 of palladin (Palld (zeige PALLD Antikörper)-Ig3).
Furthermore, this F-actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin (zeige OTOF Antikörper)-dependent exocytosis and its sensitivity to intracellular hydrostatic pressure.
These findings evidence alpha-actinin involvement in sarcomeric development, suggesting for this protein an important role in stabilizing the muscle contractile apparatus.
The C-terminal polybasic region of CYTH2 (zeige CYTH2 Antikörper) participates in interacting directly with the EFh2 domain of ACTN1.
Actn1 differential methylation occurs in diverse mouse tissues. Authors have found no indication of an imprinted effect on gene expression of Actn1 in mice.
alpha-actinin has a role in adhesion maturation through integrin-dependent force transmission to the extracellular matrix
Alpha-actinin interaction with syndecan-4 (zeige SDC4 Antikörper) has a role in stabilising cell-matrix adhesion.
the SRF-cofilin-actin signaling axis modulates neuronal mitochondrial function
vinculin (zeige VCL Antikörper) engagement of adhesion receptors first activates talin or alpha-actinin, by provoking structural changes that allow their vinculin (zeige VCL Antikörper) binding sites to swing out, which are then sufficient to bind to and activate vinculin (zeige VCL Antikörper)
Surface biotinylation and flow cytometry assays revealed that L-type calcium channel alpha(1C) channels composed of the corresponding alpha-actinin-binding-deficient mutants result in a 35-40% reduction in surface expression compared to that of wild-type channels.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
actinin, alpha 1
, alpha actinin
, F-actin cross-linking protein
, actinin 1 smooth muscle
, alpha-actinin cytoskeletal isoform
, non-muscle alpha-actinin-1
, alpha actinin 1a
, non-muscle alpha-actinin 1
, alpha-actinin 1