CD46 Proteine
(CD46)
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].
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CD46
Spezies: Hund
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD46
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD46
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
Greater than 95 % as determined by SDS-PAGE
WB, ELISA
1 image
CD46
Spezies: Human
Wirt: Wheat germ
Recombinant
WB, ELISA, AP, AA
1 image
CD46
Spezies: Human
Wirt: Baculovirus infected Insect Cells
Recombinant
> 90% by SDS-PAGE
SDS
1 image
CD46
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
CD46
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
SDS, WB, ELISA
CD46
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
SDS, WB, ELISA
CD46
Spezies: Human
Wirt: Mammalian Cells
Recombinant
>90 % as determined by SDS-PAGE.
SDS, WB, ELISA, Imm, AcA
Active
CD46
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 97 %
SDS, WB, Imm, PC
CD46
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS, WB, Imm, PC
CD46
Spezies: Ratte
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS, WB, Imm, PC
CD46
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 85 % pure
SDS
CD46
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
CD46
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %
SDS, WB, ELISA, IP
1 image
CD46
Spezies: Ratte
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %
SDS, WB, ELISA, IP
1 image
CD46
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
Aktuelle Publikationen für unsere CD46 Proteine
: "Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions." in: Nature communications, Vol. 10, Issue 1, pp. 741, (2019) (PubMed).: "CD46 facilitates entry and dissemination of human cytomegalovirus." in: Nature communications, Vol. 10, Issue 1, pp. 2699, (2019) (PubMed).
: "C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells." in: Virus research, Vol. 179, pp. 231-4, (2014) (PubMed).
: "Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?" in: Journal of neuroimmunology, Vol. 276, Issue 1-2, pp. 172-4, (2014) (PubMed).
Aliase für CD46 Proteine
CD46 molecule (CD46) ProteineCD46 antigen, complement regulatory protein (Cd46) Proteine
CD46 molecule (Cd46) Proteine
CD46 molecule, complement regulatory protein (CD46) Proteine
membrane cofactor protein-like (LOC100341359) Proteine
membrane cofactor protein-like (LOC103789310) Proteine
AHUS2 Proteine
CD46 Proteine
MCP Proteine
Mcp Proteine
MIC10 Proteine
TLX Proteine
TRA2.10 Proteine
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