The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].
custom-made
CD40LG
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
CD40LG
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Aktuelle Publikationen für unsere CD40 Ligand Proteine
Kaltenmeier, Gawanbacht, Beyer, Lindner, Trzaska, van der Merwe, Härter, Grüner, Fabricius, Lotfi, Schwarz, Schütz, Hönig, Schulz, Kern, Bommer, Schrezenmeier, Kirchhoff, Jahrsdörfer: "CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3768-77, (2015) (PubMed).
Guarda, Dostert, Staehli, Cabalzar, Castillo, Tardivel, Schneider, Tschopp: "T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes." in: Nature, Vol. 460, Issue 7252, pp. 269-73, (2009) (PubMed).
French, Huard, Wysocka, Shane, Contassot, Arrighi, Piguet, Calderara, Rook: "Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sézary syndrome: circumvention by hexameric soluble CD40L." in: Blood, Vol. 105, Issue 1, pp. 219-25, (2004) (PubMed).
Holler, Tardivel, Kovacsovics-Bankowski, Hertig, Gaide, Martinon, Tinel, Deperthes, Calderara, Schulthess, Engel, Schneider, Tschopp: "Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1428-40, (2003) (PubMed).