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These studies showed that VCAM1 contributes not only to the initiation of myelination but also to its regulation through controlling the abundance of CD69, demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS.
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Results showed that MOVACs transfected with pCMV5-HA-RKIP significantly inhibited TNF-a induced mRNA and protein expression of ICAM-1 and VCAM-1.
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VCAM-1 promotes CD34(+)VLA-4(+) cell mobilization into the damaged myocardial tissues.
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These studies define differential roles for VCAM-1 in SC depending on the state of their niche.
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sVCAM-1 is a novel chemoattractant for neutrophils and an activator for alveolar macrophages
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VCAM1 affects the neural stem cells fate by signaling through its intracellular domain to regulate beta-catenin signaling in a context-dependent manner
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Reducing Cadm1 expression in the hypothalamus and hippocampus promoted a negative energy balance and weight loss
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Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respectively; expression of the latter was upregulated in obesity.
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High VCAM1 expression is associated with Experimental Autoimmune Myocarditis
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Aortic VCAM-1 was expressed early and indicated vascular inflammation in collagen-induced arthritis.
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this manuscript shows that endothelial cell FAK activity induces VCAM-1 expression and contributes to atherosclerosis
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Gas6-FoxO-1 signaling axis plays an important role in VCAM-1 expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
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These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1.
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Repeated social defeat-induced VCAM-1 protein expression were localized to the vasculature of brain regions implicated in fear and anxiety responses.
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neutrophils are reliant on endothelial activation for adhesion, initially via E-selectin and subsequently, by integrin-mediated binding to ICAM-1 and VCAM-1, combined with CXCL8-dependent chemotaxis.
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PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
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Activation of Wnt/beta-catenin signaling in AECs attenuated intercellular adhesion molecule 1 (ICAM-1)/vascular cell adhesion molecule 1 (VCAM-1)-mediated adhesion of both macrophages and neutrophils to AECs.
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a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18/IL-18BP pathway, leading to increased VCAM-1 expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes
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Succinobucol loaded nanoparticles suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression
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Inactivating the 5' NF-kappaB element in the Vcam1 promoter and altering 3 nucleotides in the 5' UTR lowered endothelial but not intimal Vcam1 expression induced by cytokines or diet-induced atherosclerosis.
