anti-TJP1 (TJP1) Antikörper

Human Tight Junction Protein 1 (Zona Occludens 1) (TJP1) Interaktionspartner

1. ZO-1 downregulation or ZONAB upregulation increases corneal ECD via interference with contact inhibition and cell cycle control. With further development, such approaches might provide a means for improving ECD in donor corneas before transplantation.

2. Up-regulated microRNA-23a in intracerebral hemorrhage patients promotes the apoptosis of cerebral vascular endothelial cells by down-regulating ZO-1.

3. the first evidence linking likely pathogenic TJP1 variants to Arrhythmogenic cardiomyopathy (ACM). Prevalence and pathogenic mechanism of TJP1-mediated ACM remain to be determined.

4. We found that the uremic arteries had lost their intact and continuous endothelial morphology, with a reduction in VE-cadherin and ZO-1 expression and that uremia alters cell-to-cell junctions leading to an increased endothelial damage.

5. leukocyte binding to VCAM-1 induces signals that stimulated ZO-1 serine phosphorylation and reduced ZO-1 localization at endothelial cell junctions during leukocyte transendothelial migration.

6. results reveal that miR-130a directly targets FOSL1 and suppresses the inhibition of ZO-1, thus inhibiting cancer cell migration and invasion, in triple-negative breast cancer.

7. Study findings show for the first time that the systemic concentration of ZO-1 was significantly elevated in Hepatocellular carcinoma (HCC) patients and is positively correlated with inflammatory markers and raise the possibility that it could be used as a potential diagnostic biomarker for HCC progression.

8. Dysfunction of the miR-455-TJP1 axis is involved in bladder cancer cell growth and metastasis.

9. The tight junction protein ZO-1 exists in stretched and folded conformations within epithelial cells, depending on actomyosin-generated force.

10. miR103 was upregulated in CRC. Overexpression of miR103 promoted CRC cell proliferation and migration in vitro, whereas downregulation of miR103 inhibited cell proliferation and migration. ZO1 was identified as a direct target of miR103, revealing its expression to be inversely correlated with miR103 expression in CRC samples.

11. SHANK3 expression correlated with ZO-1 and PKCepsilon in colonic tissue of patients with Crohn's disease. The expression level of SHANK3 affects ZO-1 expression and the barrier function in intestinal epithelial cells.

12. These results indicate the varying effects of 7-oxygenated cholesterol molecules on the expression and localization of ZO-1 depending on cell types, and suggest the contribution of 7-oxygeneted cholesterol molecules to the structural alteration of tight junctions.

13. CTR activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3.

14. the Ras signaling pathway is involved in HIV-1 Tat-induced changes in ZO-1 and NEP.

15. decreased interaction between ZO-1 and occludin might contribute to the epiphora occurred in the transplanted submandibular glands

16. integration of claudin-2, occludin and ZO-1 is necessary for maintaining the function of the proximal tubular epithelium.

17. Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin and zonula occludens 1.

18. The role of estrogens in the regulation of ZO-1 and estrogen receptors 1 and 2 was evaluated in human primary gut tissues by immunohistochemistry, immunofluorescence and qPCR.

19. Aberrant expression of the tight junction molecules claudin-1 and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma cells.

20. ZO-1-occludin interactions regulate multiple phases of epithelial polarization by providing cell-intrinsic signals that are required for single lumen formation.

Mouse (Murine) Tight Junction Protein 1 (Zona Occludens 1) (TJP1) Interaktionspartner

1. In SAMP10 mice, in addition to preventing a decrease in the naive T cell ratio, aging-associated skin thinning was suppressed histologically and the expression of representative tight junction genes, such as Claudin-1 and Zo-1, was increased.

2. Our results revealed the mechanism of ZO-1 expression reduced by GM-CSF, and provided a potential target, miR-96, which could block ZO-1 down-regulation caused by GM-CSF in brain microvascular endothelial cells

3. leukocyte binding to VCAM-1 induces signals that stimulated ZO-1 serine phosphorylation and reduced ZO-1 localization at endothelial cell junctions during leukocyte transendothelial migration.

4. multiple ZO-1-mediated interactions contribute to coordination of epithelial actomyosin function and genesis of unified apical surfaces.

5. Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 and ZO-2 genes accelerated the defects observed in ZO-1 knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1-dependent regulation of podocyte filtration barrier.

6. the endothelial barrier was preserved in respiratory epithelium isolated from MCU-/- mice after exposure to IL-13. In the ovalbumin-model of allergic airway disease, MCU deficiency resulted in decreased apoptosis within the large airway epithelial cells. Concordantly, expression of the tight junction protein ZO-1 was preserved, indicative of maintenance of epithelial barrier function

7. Busulfan treatment down-regulated the epididymal expression of vimentin and zonula occludens-1 (ZO-1).

8. At 3days after the first tamoxifen injection, Akt1(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43) and connexin-interacting protein zonula occludens-1 (ZO-1). Furthermore, Akt1/2 silencing significantly decreased both Cx43 and ZO-1 expression

9. Overexpression of SHANK3 enhanced ZO-1 expression, and knockdown of SHANK3 resulted in decreased expression of ZO-1. Regulation of ZO-1 expression by SHANK3 seems to be mediated through a PKCepsilon-dependent pathway. The expression level of SHANK3 affects ZO-1 expression and the barrier function in intestinal epithelial cells in mice.

10. Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin and zonula occludens 1.

11. STAT3 activation downregulates the ZO-1 and occludin levels and increases the endothelial permeability through the induction of VEGF production in retinal endothelial cells.

12. Cx43 tethers the F-actin cytoskeleton through a ZO-1 linker and supports cell spreading and exploration during locomotion in cerebral endothelial cells.

13. Expression of Podocalyxin, which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin.

14. Zonula occludens-1, occludin and E-cadherin expression and organization in salivary glands

15. Tjp1 expression was decreased in glomerular diseases in human and animal models, our results indicate that the suppression of Tjp1 could directly aggravate glomerular disorders, highlights Tjp1 as a potential therapeutic target.

16. Arecoline increases the production of TNF-alpha and induces protein redistribution of ZO-1.

17. Vcl plays a crucial role in stabilizing gap junctions and myocyte integrity through direct interactions with ZO-1 and stabilization of CX43.

18. Activation of RhoA/ROCK1 by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin/ZO-1, which can be corrected by simvastatin.

19. Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C epsilon-mediated zona occludens-1 phosphorylation at threonine 770/772.

20. The JAM-A and ZO-1 genes were highly expressed in all the tested tissues.

Cow (Bovine) Tight Junction Protein 1 (Zona Occludens 1) (TJP1) Interaktionspartner

1. cyclic strain modulates both the expression and phosphorylation state of occludin and ZO-1 in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity

Pig (Porcine) Tight Junction Protein 1 (Zona Occludens 1) (TJP1) Interaktionspartner

1. ZO-1 and occludin are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin at the blastocyst stage.

2. Zinc supplementation diet in weanling pigs showed higher levels of this protein and increased intestinal permeability.