RAMP1 Proteine (RAMP1)

Rhesus Monkey Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1) Interaktionspartner

1. Study provides accurate validation of functional CGRP (zeige CALCA Proteine) receptor expression throughout the brainstem and the spinal cord of non-human primates: several areas in the brainstem were shown to express CLR (zeige DCLK3 Proteine) and RAMP1 mRNA and protein

Mouse (Murine) Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1) Interaktionspartner

1. the cardiovascular response of Ramp1(-/-), Ramp2 (zeige RAMP2 Proteine)(+/-), Ramp3 (zeige RAMP3 Proteine)(-/-), Ramp1(-/-)/Ramp3 (zeige RAMP3 Proteine)(-/-) double-knockout (dKO), and Calcrl (zeige CALCRL Proteine)(+/-) mice to AM and CGRP (zeige CALCA Proteine) were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR (zeige CALCR Proteine)/RAMP1 heterodimer, but that AM signaling via CLR (zeige CALCR Proteine)/RAMP2 (zeige RAMP2 Proteine) and CLR (zeige CALCR Proteine)/RAMP3 (zeige RAMP3 Proteine) also contributes to some hypotensive action.

2. RAMP1 signaling improves lymphedema and accelerates lymphangiogenesis associated with reduced recruitment of pro-inflammatory macrophages.

3. RAMP1 exerted mucosal protection in DSS (zeige PMP22 Proteine)-induced colitis via attenuation of recruitment of inflammatory cells and of pro-inflammatory cytokines.

4. Together, these data indicate that signaling through RAMP1 and CLR (zeige CALCR Proteine) plays a role in mediating asthma pathology

5. multiple NKX3.1 (zeige NKX3-1 Proteine) binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate.

6. Data indicate that IL-17 (zeige IL17A Proteine) production is suppressed in RAMP1-deficient mice in the experimental autoimmune encephalomyelitis (EAE) model and RAMP1-deficient mice are completely resistant to EAE.

7. Data indicate that the lack of an intact CGRP receptor component (zeige CRCP Proteine) RAMP1 resulted in an increased recruitment and activation of neutrophils.

8. Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (zeige RAMP3 Proteine), but not of intermedin (IMD (zeige ADM2 Proteine)), calcitonin receptor-like receptor (CRLR (zeige CALCRL Proteine)), and RAMP1 and RAMP2 (zeige RAMP2 Proteine).

9. significantly diminished intestinal peristalsis was observed by the allergy induction in RAMP1-deficient mice compared with WT mice.

10. These findings suggest that RAMP1 may be a new therapeutic target to regulate CGRP (zeige CALCA Proteine)-mediated effects during disease including pathophysiological states in which Ang II (zeige AGT Proteine) plays a major role.

Human Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1) Interaktionspartner

1. T-A-T RAMP1 gene haplotype might have utility as a genetic marker for Essential Hypertension and that the RAMP1 gene may be associated with increased susceptibility to Essential Hypertension in a Japanese population.

2. Data suggest CGRP (zeige S100A12 Proteine) receptor (CGRPR (zeige CALCRL Proteine)) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP (zeige S100A12 Proteine); this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP (zeige S100A12 Proteine)/CGRPR (zeige CALCRL Proteine) interaction; CGRPR (zeige CALCRL Proteine) is obligate heterodimer of CLR (zeige DCLK3 Proteine)/RAMP1. (CGRP (zeige S100A12 Proteine) = calcitonin gene-related peptide (zeige CALCA Proteine); CLR (zeige DCLK3 Proteine) = calcitonin receptor-like receptor (zeige CALCRL Proteine); RAMP1 = receptor [calcitonin (zeige CALCA Proteine)] activity modifying protein 1)

3. Evidence that DNA methylation (zeige HELLS Proteine) at RAMP1 gene promoter plays a role in migraine was described.

4. RAMP1 rs7590387 has a role in the transformation of episodic migraine into medication overuse headache.

5. Data suggest that ligand binding of a G protein-coupled receptor (GPCR (zeige TAS1R3 Proteine)) may inform drug development targeting calcitonin receptor-like receptor (CLR (zeige CALCRL Proteine)):receptor activity-modifying proteins RAMP1/2 complexes.

6. A novel functional role for RAMP1 in regulation of CaSR (zeige CASR Proteine) signalling in addition to its known role in receptor trafficking, is reported.

7. multiple NKX3.1 (zeige NKX3-1 Proteine) binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate.

8. RAMP1 overexpression enhances the promoting effect that exogenous CGRP (zeige S100A12 Proteine) has on osteogenic differentiation

9. No significant association of the tested SNPs of the RAMP1 gene were found with migraine susceptibility.

10. CLR (zeige DCLK3 Proteine) and RAMP1 co-localize in the enteric nervous system of human stomach, ileum, and colon, and are in close proximity to their ligands CGRP (zeige S100A12 Proteine) and IMD (zeige ADM2 Proteine)