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P2Y(11) is transcribed during embryonic development, beginning at gastrulation, and is enriched in the developing nervous system.
a major role for P2X7R and P2Y11R in ATP-mediated inhibition of tumor-derived endothelial cell migration, is reported.
these results show hepatocellular carcinoma-specific expression of the P2Y11 receptor and its critical role in mediating ATP-inducing Ca2+ signalling and regulating cancer cell migration
Decreased P2Y11 signaling plays an important role in the development of narcolepsy with cataplexy.
Hypoxia/reoxygenation inhibits P2y11 receptor expression and its immunosuppressive activity in human dendritic cells.
Suggest role for LXA4 in stimulating apical ATP secretion via pannexin-1 channels and P2RY11 purinoreceptors activation leading to an airway surface liquid layer height increase and epithelial repair.
the physiological impact of A87T mutation of the P2Y11 receptor derives from detrimental effects on P2Y1-P2Y11 receptor interaction.
vesicular exocytosis of ATP and autocrine, positive feedback through P2Y11 receptors is required for the effective activation of macrophages
P2Y11 receptor mediates interferon gamma-induced IL-6 production in HaCaT cells, suggesting the importance of purinergic signaling in interferon-gamma induced skin inflammatory conditions
P2Y11 receptors are abundantly and diffusely expressed intracellularly in skeletal muscle fibers.
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population.
Extracellular NAD stimulates mesenchymal stem cell functions through activation of P2Y11 receptor.
Common variants in P2RY11 are associated with narcolepsy.
Inhibition of Natural killer cell response to CX3CL1 is mediated by the P2Y11 receptor.
expression profile in human peripheral tissues and brain regions using PCR
beta-NAD(e)+ is an agonist of the P2Y(11) purinoceptor and P2Y(11) is the endogenous receptor in granulocytes mediating the sustained [Ca2+]i increase responsible for their functional activatio
We propose that residues Arg106, Arg268, Arg307 and Glu186 are involved in ionic interactions with the phosphate moiety of ATP. Arg307 is possibly also H-bonded to N6 of ATP via the backbone carbonyl.
In human granulocytes, endogenous P2Y(11) proved to be responsible for NAADP+-induced cell activation, unveiling a role of NAADP+ as a pro-inflammatory cytokine.
oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor
The P2 receptor mediating the antiapoptotic actions of ATP was identified using a combination of more selective ATP analogs, receptor expression studies, and study of downstream signaling pathways.
present data clearly show that P2Y purinoceptor 11 and P2Y purinoceptor 12 are expressed in human pancreatic islets
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
G-protein coupled receptor
, P2Y purinoceptor 11-like
, P2Y purinoceptor 11
, purinergic receptor P2Y11