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C-Type Lectin Domain Family 4, Member M Proteine

(C-Type Lectin Domain Family 4, Member M (CLEC4M))
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009].

13 Treffer

custom-made CLEC4M Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7553516
 
CLEC4M Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Produktnummer ABIN7504305
 
CLEC4M Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7504304
 
CLEC4M Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA
Produktnummer ABIN7575759
 
CLEC4M Spezies: Human Wirt: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. SDS, WB, ELISA, Imm, AcA Active
Produktnummer ABIN7607714
 
CLEC4M Spezies: Human Wirt: Mammalian Cells Recombinant SDS, WB, ELISA
Produktnummer ABIN7575758
 
CLEC4M Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 97 % SDS, WB, Imm, PC
Produktnummer ABIN7413766
 
CLEC4M Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7194490
 
CLEC4M Spezies: Human Wirt: Baculovirus infected Insect Cells Recombinant > 95% by SDS - PAGE SDS
Produktnummer ABIN7596335
 
custom-made CLEC4M Spezies: Human Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA
Produktnummer ABIN3118083
 
CLEC4M Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2713616
 
CLEC4M Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2716811
 
CLEC4M Spezies: Schimpanse Wirt: Hefe Recombinant > 90 % ELISA
Produktnummer ABIN1636713
 
  • Typ Protein
    • Protein
  • Anwendung
    • SDS-PAGE (SDS)
    • ELISA
    • Western Blotting (WB)
    • Antibody Production (AbP)
    • Immunogen (Imm)
    • Standard (STD)
    • Activity Assay (AcA)
    • Positive Control (PC)
  • Reaktivität
    • Human
    • Chimpanzee
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • HEK-293 Cells
    • Escherichia coli (E. coli)
    • Mammalian Cells
    • Baculovirus infected Insect Cells
    • Cell-free protein synthesis (CFPS)
    • Yeast
  • Bindungsspezifität
    • AA 1-399
    • AA 71-399
    • AA 242-399
    • AA 71-445
    • AA 72-399
    • AA 73-376
    • Transcript Variant 1
    • Transcript Variant 2
  • Konjugat
    • His tag
    • Fc Tag
    • Myc-DYKDDDDK Tag
    • His-DYKDDDDK Tag
    • Strep Tag
    • hIgG-His-tag
    • Unkonjugiert
  • Protein-Typ
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biologische Aktivität
    • Biologically Active
  • Grade
    • custom-made
  • Hersteller
    • antibodies-online
    • OriGene
    • CUSABIO

Aliase für C-Type Lectin Domain Family 4, Member M Proteine

C-type lectin domain family 4 member M (CLEC4M) Proteine
CD209B Proteine
CD209L Proteine
CD299 Proteine
DC-SIGN2 Proteine
DC-SIGNR Proteine
DCSIGNR Proteine
HP10347 Proteine
L-SIGN Proteine
LSIGN Proteine
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