(Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity).
custom-made
BRE
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
BRE
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
BRE
Spezies: Maus
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
BRE
Spezies: Human
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
BRISC and BRCA1 A complex member 2 (babam2) Proteine BRISC and BRCA1 A complex member 2 (BABAM2) Proteine BRISC and BRCA1 A complex member 2 (Babam2) Proteine brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE) Proteine BRISC and BRCA1 A complex member 2 L homeolog (babam2.L) Proteine 6030405P19Rik Proteine AI429776 Proteine B830038C02Rik Proteine brcc4 Proteine BRCC4 Proteine brcc45 Proteine BRCC45 Proteine BRE Proteine im:7141046 Proteine LOC100231620 Proteine zgc:110368 Proteine