The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008].
Myllärniemi, Lindholm, Ryynänen, Kliment, Salmenkivi, Keski-Oja, Kinnula, Oury, Koli: "Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis." in: American journal of respiratory and critical care medicine, Vol. 177, Issue 3, pp. 321-9, (2008) (PubMed).
Celeste, Iannazzi, Taylor, Hewick, Rosen, Wang, Wozney: "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9843-7, (1991) (PubMed).
Ozkaynak, Rueger, Drier, Corbett, Ridge, Sampath, Oppermann: "OP-1 cDNA encodes an osteogenic protein in the TGF-beta family." in: The EMBO journal, Vol. 9, Issue 7, pp. 2085-93, (1990) (PubMed).
Aliase für BMP7 Proteine
bone morphogenetic protein 7 (BMP7) Proteine bone morphogenetic protein 7, gene 1 L homeolog (bmp7.1.L) Proteine bone morphogenetic protein 7 (LOC100136282) Proteine bone morphogenetic protein 7b (bmp7b) Proteine bone morphogenetic protein 7 (Bmp7) Proteine bone morphogenetic protein 7 (LOC100008826) Proteine bone morphogenetic protein 7, gene 2 L homeolog (bmp7.2.L) Proteine bone morphogenetic protein 7a (bmp7a) Proteine bmp-7 Proteine BMP-7 Proteine bmp7 Proteine BMP7 Proteine fb83f09 Proteine op-1 Proteine OP-1 Proteine OP1 Proteine wu:fb83f09 Proteine zgc:153025 Proteine