The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].
custom-made
BAX
Spezies: Maus
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
BAX
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
custom-made
BAX
Spezies: Maus
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
BAX
Spezies: Human
Wirt: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
Aktuelle Publikationen für unsere BCL2-Associated X Protein Proteine
Mishra, Sharma, Sharma, Singh, Sardesai, Sharma, Mishra: "Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells." in: Journal of ethnopharmacology, Vol. 219, pp. 91-102, (2018) (PubMed).
Kim, Kim, Park, Hwang, Kim, Lee, Kang, Um: "Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax." in: Cellular signalling, Vol. 24, Issue 6, pp. 1163-72, (2012) (PubMed).
Chattopadhyay, Marques, Yamashita, Peters, Smith, Desai, Williams, Sen: "Viral apoptosis is induced by IRF-3-mediated activation of Bax." in: The EMBO journal, Vol. 29, Issue 10, pp. 1762-73, (2010) (PubMed).
Wang, Carlsson, Basso, Zhu, Rousset, Rasola, Johansson, Blomgren, Mallard, Bernardi, Forte, Hagberg: "Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 8, pp. 2588-96, (2009) (PubMed).
Bras, Yuste, Roué, Barbier, Sancho, Virely, Rubio, Baudet, Esquerda, Merle-Béral, Sarfati, Susin: "Drp1 mediates caspase-independent type III cell death in normal and leukemic cells." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7073-88, (2007) (PubMed).
Aliase für BCL2-Associated X Protein Proteine
BCL2 associated X, apoptosis regulator (BAX) Proteine BCL2-associated X protein L homeolog (bax.L) Proteine BCL2-associated X protein (bax) Proteine bcl2-associated X protein, a (baxa) Proteine BCL2-associated X protein (Bax) Proteine BCL2 associated X, apoptosis regulator (Bax) Proteine bcl2-associated X protein, b (baxb) Proteine BAX Proteine bax Proteine bax-A Proteine BAX-ALPHA Proteine BCL2L4 Proteine fj16e01 Proteine wu:fc50b10 Proteine wu:fj16e01 Proteine xBax Proteine xlbax Proteine zgc:112983 Proteine