anti-Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1) Antikörper

Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1) Interaktionspartner

1. Among 29 immune and inflammatory proteins, CXCL1, CD84 and TNFRSF10A were associated with early post-acute coronary syndrome (ACS) after initial ACS-admission

2. These results suggest that secretion of the myokine CXCL1 is stimulated by saturated fatty acids and that CXCL1 promotes myogenesis from satellite cells to maintain skeletal muscle homeostasis.

3. Sputum CXCL1 levels in chronic obstructive pulmonary disease andasthma-COPD overlap patients were higher than in interstitial pneumonia

4. Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes.

5. By inducing glycolysis, CXCL1 plays a crucial role in both cancer progression and metastasis in colorectal cancer patients.

6. Adiponectin treatment of ovarian cancer cells induces angiogenesis via CXC chemokine ligand 1 independently of vascular endothelial growth factor. These findings suggest that adiponectin may serve as a novel therapeutic target for ovarian cancer.

7. CXCL1 gene expression was associated with the negative syndrome in non-deficit schizophrenia patients, while no association in deficit schizophrenia was observed.

8. GRO-alpha from OSF-associated fibroblasts paracrinally promotes oral malignant transformation and significantly contributes to OSCC development.

9. Both GRO-alpha and IL-8 can activate TAK1/NFkappaB signaling via the CXCR2 receptor.

10. Results show that the expression of CXCL1 and CXCL2 in tumor cells and tumor-infiltrated CD11b+ myeloid cells is critically involved in the promotion of the generation of monocytic myeloid-derived suppressor cells (mo-MDSC) from bone marrow cells. CXCL1 and CXCL2 were found to specifically promote the expansion of mo-MDSC rather than granulocytic MDSC (G-MDSC).

11. The chemokine Gro1 induced in response to inflammation triggers senescence and arrests development of new neurons in the hippocampus and that the magnitude of this response is sex-dependent.

12. CXCL1 displays a specific microRNA (miR) upregulated by the prototypical colon cancer onco-miR miR-105.

13. These results show that AKIP1 is crucial in cervical cancer angiogenesis and growth by elevating the levels of the NF-kappaB-dependent chemokines CXCL1, CXCL2, and CXCL8.

14. Adipose stromal cells recruitment to tumours, driven by CXCL1 and CXCL8, promotes prostate cancer progression.

15. CXCL1, which is produced by breast cancer cells, can promote cancer growth and development

16. miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A.

17. Thrombocytosis was more prevalent in patients with inflammatory breast cancer (IBC)than in those with non-IBC and it was associated with poor prognosis. GRO and TGF-beta were associated with thrombocytosis in IBC

18. the plasma concentrations of CXCL1 indicated the disease activity and prognosis in interstitial pneumonia with autoimmune features (IPAF). Thus, the CXCL1/CXCR2 axis appears to be involved in the progression of IPAF.

19. CXCL1/8 secreted by adipose-derived mesenchymal stem cells could promote breast cancer angiogenesis.

20. GROA overexpression is associated with invasion in triple negative breast cancer.

Mouse (Murine) Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1) Interaktionspartner

1. These results suggest that secretion of the myokine CXCL1 is stimulated by saturated fatty acids and that CXCL1 promotes myogenesis from satellite cells to maintain skeletal muscle homeostasis.

2. Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 are involved in neutrophil emigration.

3. Data suggest that microglia relied on caspase recruitment domain-containing protein 9 (CARD9) for production of interleukin-1beta (IL-1beta), inflammasome activation and of chemokine CXCL1 (CXCL1) in the fungus-infected central nervous system (CNS).

4. CXCL1, CXCL2 and CCL2 binding to the glomerular endothelial glycocalyx appears differentially mediated by specific Heparan sulfate domains.

5. The increase of C-X-C motif chemokine ligand (cxcl)-1 gene expression was statistically significant at 2 days and 2 wks after injury.

6. Data suggest that CD4+ T lymphocytes and microglial CD40 mediate their pro-nociceptive effects in part by promoting selected chemokine responses, and more importantly, CXCL1 can play an anti-nociceptive role in peripheral nerve injury-induced neuropathic pain, which is possibly mediated by infiltrating neutrophils.

7. Adipose stromal cells recruitment to tumours, driven by CXCL1 and CXCL8, promotes prostate cancer progression.

8. The results demonstrate that C57BL/6J mice have a functional defect in NLRP12, impaired CXCL1 production, and that macrophages require NLRP12 expression for effective recruitment of neutrophils to inflammatory sites.

9. GAG interactions and receptor activity of CXCL1 monomers and dimers are fine-tuned to regulate neutrophil trafficking for successful resolution of tissue injury.

10. a paracrine role for Hippo-mediated secretion of CXCL1 and CXCL2 in the production of anti-microbial peptides (beta-defensins), iNOS, NOX2 and pro-inflammatory molecules during mycobacterial infection of the host, is reported.

11. this study demonstrates that in vivo blocking of CXCL1 and CXCL2 can significantly reduce the Mycobacterium tuberculosis-induced bioactive IL-1beta production

12. RelA has a role in regulating OIS in preneoplastic lesions; the RelA/CXCL1/CXCR2 axis is an essential mechanism of tumor surveillance in pancreatic ductal adenocarcinoma

13. CXCL1 contributed to rapid neutrophil recruitment during Bacillus cereus endophthalmitis. In CXCL1-knockout mice, retinal function was greater and neutrophil influx was less than in control mice, confirming its role in ocular inflammation.

14. Interferon-gamma (IFN-gamma) up-regulated interleukin 6 (IL-6) and CXCL1 chemokine (CXCL1) production of bone marrow mesenchymal stem cells (mBM-MSC).

15. Our work deciphers the mCXCL1-mTORC1 pathway as crucial in liver cancer stem cell maintenance

16. MMP7 shedding of syndecan-1/CXCL1 complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury.

17. Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 and (C-X-C motif) ligand 1 (CXCL1).

18. CXCR2/CXCL1 axis promotes granulocytic myeloid-derived suppressor cells recruitment and facilitates arginase I expression and activity of these cells at maternal-fetal interface

19. The novel findings reveal the critical role of NLRP12-IL-17A-CXCL1 axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae.

20. Nlrp12 deficiency caused increased neutrophil migration towards the chemokine CXCL1 and the neutrophil parasite Leishmania major, revealing NLRP12 as a negative regulator of directed neutrophil migration under these conditions.