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anti-Human ATG3 Antikörper:
anti-Mouse (Murine) ATG3 Antikörper:
anti-Rat (Rattus) ATG3 Antikörper:
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Human Polyclonal ATG3 Primary Antibody für WB - ABIN1882157
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
Show all 6 Pubmed References
PTK2 (zeige PTK2 Antikörper) inhibition-induced sustained levels of ATG3 were able to sensitize cancer cells to DNA-damaging agents.
Our data demonstrate that HOTAIR promotes the activation of autophagy in HCC (zeige FAM126A Antikörper) cells by upregulating the expression of the autophagy-related genes ATG3 and ATG7 (zeige ATG7 Antikörper).
ATG3 upregulation contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells
Hidden Markov models were used to detect protein homology among the flexible regions of Atg3 homologs and importance of conserved regions evaluated by performing affinity capture experiments with human Atg3 deletion constructs; binding studies and competition experiments demonstrate that overlapping sites in the Atg3FR are important for E3 binding and E1 binding.
The region of human ATG3 that interacts with ATG7 (zeige ATG7 Antikörper) is precisely identified using nuclear magnetic resonance.
ATG3 gene and its gene family may play an important role in transformation of myelodysplastic syndrome.
Lipidation of the LC3 (zeige MAP1LC3A Antikörper)/GABARAP (zeige GABARAP Antikörper) family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.
13 residues of the ATG3 fragment form a short beta-strand followed by an alpha-helix on a surface area that is an exclusive binding site for ATG12.
caspase-8 (zeige CASP8 Antikörper) overexpression led to Atg3 degradation and this event depended on caspase-8 (zeige CASP8 Antikörper) enzymatic activity
These results unveil a role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation.
A thiol-dependent process is being reported that may account for impaired autophagy during aging. This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 and Atg7 (zeige ATG7 Antikörper).
These findings highlight a critical role of ATG3-dependent autophagy for mitochondrial homeostasis regulation in both pluripotency acquirement and maintenance.
miR (zeige MLXIP Antikörper)-495 targets ATG3 and regulates its protein levels under starvation conditions. miR (zeige MLXIP Antikörper)-495 also inhibits starvation-induced autophagy by decreasing the number of autophagosomes.
ATG12 (zeige ATG12 Antikörper)-ATG3 interacts with Alix (zeige PDCD6IP Antikörper) to promote basal autophagic flux and late endosome function.
Atg3 expression, similar to Atg5 expression, is required for Immunity Related GTPases and Guanylate binding proteins to dock to pathogen-containing vacuoles.
Vaccinia virus actively disrupts the cellular autophagy through a novel molecular mechanism that is associated with aberrant LC3 (zeige MAP1LC3A Antikörper) lipidation and a direct conjugation between ATG12 (zeige ATG12 Antikörper) and ATG3.
The model and biochemical data provide a rationale for Atg7 (zeige ATG7 Antikörper) dimerization: Atg8 (zeige MAP1LC3B Antikörper) is transferred in trans from the catalytic cysteine of one Atg7 (zeige ATG7 Antikörper) protomer to Atg3 bound to the N-terminal domain of the opposite Atg7 (zeige ATG7 Antikörper) protomer within the homodimer.
Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential for autophagy (Tanida et al., 2002
, autophagy-related protein 3
, ubiquitin-like-conjugating enzyme ATG3
, ATG3 autophagy related 3 homolog
, autophagy-related 3
, preconditioning-inducible gene 1 protein
, potential E2-like lipid conjugating enzyme Atg3