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Human VPS18 Protein expressed in Wheat germ - ABIN1325048
van der Kant, Fish, Janssen, Janssen, Krom, Ho, Brummelkamp, Carette, Rocha, Neefjes: Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L. in Journal of cell science 2013
important roles of Vps18 in neuron survival and migration, which are disrupted in multiple neural disorders.
Vps18 deficiency severely blocks the dendrite development of Pukinje cells but not cerebral cortical neurons.
Study characterized the ubiquitinomes of Vps11/18 and demonstrated that these two factors are involved in the regulation of signal transduction by protein ubiquitination. VPS11/18 regulate several signaling factors and pathways, including Wnt, estrogen receptor alpha (ERalpha), and NFkappaB.
VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction
Depletion of hVps18 or hMon2 reduced the efficient production of infectious HIV-1 virions in human cells.
hVPS18 may play an important role in regulation of SNK activity through its ubiquitin ligase
ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18
Mutation of the class C vacuolar protein sorting gene vps18 results in hepatomegaly associated with large, vesicle-filled hepatocytes.
A deficiency of Vps18 in zebrafish larvae results in hepatomegaly and skin hypopigmentation.
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
vacuolar protein sorting protein 18
, vacuolar protein sorting 18 homolog
, vacuolar protein sorting 18 homolog (S. cerevisiae)
, subunit of the VPS-C complex
, Pep3/Vps18/deep orange domain-containing protein
, vacuolar protein sorting-associated protein 18 homolog