ASPM Antikörper
(Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
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Ausgewählte ASPM Kategorien
ASPM Antikörper
High quality antibodies with extensive validation data.
Empfohlene ASPM Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN7142932
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IF
Validierungen
- (3)
Kat. Nr.
ABIN7259793
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human, Rat
Applikation
ELISA, IHC, IF, ICC, WB
Validierungen
- (3)
Kat. Nr.
ABIN6260082
Menge
100 μL
Datenblatt
Datenblatt
Neueste Publikationen zu unseren ASPM Produkten
: "Identification of Abnormal Spindle Microtubule Assembly as a Promising Therapeutic Target for Osteosarcoma." in: Orthopaedic surgery, Vol. 12, Issue 6, pp. 1963-1970, (2021) (PubMed).: "NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells." in: The EMBO journal, Vol. 39, Issue 2, pp. e102378, (2020) (PubMed).
: "Abnormal spindle-like microcephaly-associated protein (ASPM) contributes to the progression of Lung Squamous Cell Carcinoma (LSCC) by regulating CDK4." in: Journal of Cancer, Vol. 11, Issue 18, pp. 5413-5423, (2020) (PubMed).
: "Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity." in: Current biology : CB, Vol. 29, Issue 18, pp. 3072-3080.e5, (2019) (PubMed).
: "Pancreatic cancer survival analysis defines a signature that predicts outcome." in: PLoS ONE, Vol. 13, Issue 8, pp. e0201751, (2018) (PubMed).
: "Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly." in: Scientific reports, Vol. 7, pp. 43708, (2017) (PubMed).
: "Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex." in: Nature cell biology, Vol. 19, Issue 5, pp. 480-492, (2017) (PubMed).
: "Time-dependent transcriptional profiling links gene expression to mitogen-activated protein kinase kinase 4 (MKK4)-mediated suppression of omental metastatic colonization." in: Clinical & experimental metastasis, Vol. 29, Issue 5, pp. 397-408, (2012) (PubMed).
: "Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling." in: Nature genetics, Vol. 40, Issue 2, pp. 232-6, (2008) (PubMed).
Synonyme und alternative Namen zu ASPM
abnormal spindle microtubule assembly (Aspm), abnormal spindle microtubule assembly (ASPM), abnormal spindle microtubule assembly (aspm), asp (abnormal spindle)-like, microcephaly associated (Drosophila) (Aspm), ASP, ASPM, Calmbp1, D330028K02Rik, MCPH5, Sha1Bezeichner auf Proteinebene für ASPM
- asp (abnormal spindle) homolog, microcephaly associated
- calmodulin binding protein 1
- asp (abnormal spindle)-like, microcephaly associated
- asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
- Abnormal spindle-like microcephaly-associated protein homolog
- abnormal spindle-like microcephaly-associated protein
- abnormal spindle-like microcephaly-associated protein homolog
- abnormal spindle-like microcephaly protein
- calmodulin-binding protein 1
- calmodulin-binding protein Sha1
- spindle and hydroxyurea checkpoint abnormal protein
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