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Human TNFSF10 Protein expressed in Wheat germ - ABIN1323209
Borbone, De Rosa, Siciliano, Altucci, Croce, Fusco: Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells. in The Journal of clinical endocrinology and metabolism 2013
RA/poly(I:C) combination synergizes to induce a bioactive autocrine/paracrine loop of type-I Interferons (IFNs) which is ultimately responsible for TRAIL and TRAIL-R1/2 expression upregulation, while inhibition of TRAIL-R3 (zeige TNFRSF10C Proteine)/4 expression is type-I IFN-independent.
our results demonstrated that nanovectorization of TRAIL with BNNTs enhanced its binding to both DR4 (zeige HLADRB4 Proteine) and DR5 (zeige TNFRSF10B Proteine) receptors at 37 degrees C. Our novel nanovector could potentially be used for delivering TRAIL to cells for cancer treatment
In primary hyperparathyroidism, hyperplasias demonstrated the highest expression of TRAIL and Fas (zeige FAS Proteine), whereas in adenomas it was increased compared to normal tissue, but lower than in hyperplasias.
we found that plumbagin could enhance TRAIL-induced apoptosis in Kasumi-1 cells, and the mechanisms include ROS (zeige ROS1 Proteine)-mediated upregulation of DR5 (zeige TNFRSF10B Proteine) expression, caspase-8 (zeige CASP8 Proteine) activation and inhibition of cFLIP (zeige CFLAR Proteine) expression
None of these crude extracts exhibited cytotoxic effect on normal mouse embryonic fibroblasts (MEF), with the exception of EGY34. Analysis of the signaling pathways underlying the sensitization of MDA-MB-231 cells to TRAIL-induced apoptosis, by western blotting, revealed that all crude extracts facilitated initiator caspase8/-10 activation upon TRAIL stimulation
Report a novel mechanism for the TRAIL-induced apoptosis of TrkAIII expressing NB cells that depends upon SHP (zeige LAMC1 Proteine)/Src (zeige SRC Proteine)-mediated crosstalk between the TRAIL-receptor signaling pathway and TrkAIII.
our findings identify a key role for c-Myc (zeige MYC Proteine) in TRAIL deregulation and as a biomarker of the anticancer action of HDACi in acute myeloid leukemia (zeige BCL11A Proteine) .
These effects of metformin were accompanied by robust reductions in the protein levels of XIAP (zeige XIAP Proteine), a negative regulator of TRAIL-induced apoptosis. Silencing XIAP (zeige XIAP Proteine) in TNBC cells mimicked the TRAIL-sensitizing effects of metformin. Metformin also enhanced the antitumor effects of TRAIL in a metastatic murine TNBC model
siRNA silencing of CHOP (zeige DDIT3 Proteine) significantly reduced cyproterone acetate-induced DR5 (zeige TNFRSF10B Proteine) up-regulation and TRAIL sensitivity in prostate cancer cells. Our study shows a novel effect of cyproterone acetate on apoptosis pathways in prostate cancer cells and raises the possibility that a combination of TRAIL with cyproterone acetate could be a promising strategy for treating castration-resistant prostate cancer.
TRAIL expression in CTLs was negatively correlated with the expression of perforin and granzyme B, and negatively correlated with CTLs apoptosis in severe aplastic anemia patients.
In this study, the authors identified by gene expression profiling that microgravity induces high levels of TRAIL expression in murine preosteoclast cells in the absence of RANKL (zeige TNFSF11 Proteine) stimulation compared to ground based cultures.
Data suggest that the CXCL9 (zeige CXCL9 Proteine)-CXCR3 (zeige CXCR3 Proteine) axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation.
Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.
TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (zeige NOX4 Proteine)/eNOS (zeige NOS3 Proteine)/nitric oxide signaling.
Study reports that loss of the Opg (zeige TNFSF11 Proteine) gene results in deterioration of abdominal aortic aneurysms (AAA (zeige AAAS Proteine)), possibly through involvement of TRAIL in smooth muscle actin (SMA (zeige SMN1 Proteine))-positive cells and myofibroblasts.
PARP1 (zeige PARP1 Proteine) acts as a prominent upstream regulator of high mobility group box 1 (zeige HMGB1 Proteine)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance
Data suggest that Socs3 (suppressor of cytokine signaling 3 (zeige SOCS3 Proteine)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (zeige MAPK8 Proteine)/AP-1 (zeige JUN Proteine) transcription factor signaling.
These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (zeige HSP70 Proteine).
These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald (zeige RDH11 Proteine) burns
Data suggest forkhead box protein O1 (FoxO1 (zeige FOXO1 Proteine)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (zeige FASL Proteine) expression during follicular atresia.
The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.
xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs (zeige SSU1 Proteine), presumably owing to PKC activation, as part of the mechanism for RBC (zeige CACNA1C Proteine) switching
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, TNF-related apoptosis inducing ligand TRAIL
, chemokine tumor necrosis factor ligand superfamily member 10
, tumor necrosis factor (ligand) family, member 10
, tumor necrosis factor apoptosis-inducing ligand splice variant delta
, tumor necrosis factor ligand superfamily member 10
, TNF-related apoptosis inducing ligand
, TNF-related apoptosis-inducing ligand
, tumor necrosis factor-related apoptosis-inducing ligand
, TNF-related apoptosis-inducing ligand 1
, tumor necrosis factor related apoptosis inducing ligand 1
, tumor necrosis factor (ligand) superfamily, member 10 like 2
, tumor necrosis factor (ligand) superfamily, member 10
, tumor necrosis factor ligand 6A
, tumor necrosis factor superfamily member 10