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Human TNFSF10 Protein expressed in Wheat germ - ABIN1323209
Borbone, De Rosa, Siciliano, Altucci, Croce, Fusco: Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells. in The Journal of clinical endocrinology and metabolism 2013
High expression level of Galectin-3 (zeige LGALS3 Proteine) and low expression level of TRAIL were found to be positively correlated with the shorter median survival time and overall survival time.
DR5 (zeige TNFRSF10B Proteine)-Cbl-b/c-Cbl (zeige CBL Proteine)-TRAF2 (zeige TRAF2 Proteine) complex inhibited TRAIL-induced apoptosis by promoting TRAF2 (zeige TRAF2 Proteine)-mediated polyubiquitination of caspase-8 (zeige CASP8 Proteine) in gastric cancer cells.
We found that the combination of alpha-mangostin with TRAIL induced apoptosis of SAS (zeige TSPAN31 Proteine) cells through the mitochondrial pathway via activation of caspase-9 (zeige CASP9 Proteine) and -3/7, following release of cytochrome c (zeige CYCS Proteine). This apoptosis was induced by S/G2 (zeige STRN3 Proteine)/M-phase arrest. Immunopositivity for c-Myc (zeige MYC Proteine) was observed in the cytoplasm of tumor cells in 16 (40%) of the 40 cases of human oral squamous cell carcinoma (HOSCC).
this study characterized in juvenile systemic lupus erythematosus a distinct profile from adult SLE that comprises increased sFas, sTRAIL, and reduced sFasL (zeige FASL Proteine), notably in patients with active disease and with nephritis.
Notch1 (zeige NOTCH1 Proteine) activation also suppressed A549 cell apoptosis by inhibiting the PI3K (zeige PIK3CA Proteine)/pAkt (zeige AKT1 Proteine) pathway and activating the caspase-3 (zeige CASP3 Proteine) pathway in cooperation with TRAIL. Combining Notch1 (zeige NOTCH1 Proteine) signal with TRAIL inhibited PI3K (zeige PIK3CA Proteine), phosphorylated Akt (zeige AKT1 Proteine) and phosphorylated STAT3 (zeige STAT3 Proteine) expressions.
we show that executioner caspase (zeige CASP3 Proteine) activation of the apoptotic nuclease (zeige DCLRE1C Proteine) CAD/DFF40 (zeige DFFB Proteine) is essential for TRAIL-induced mutations in surviving cells. As exposure to chemotherapy drugs also activates apoptotic caspases and presumably CAD, we hypothesized that these pathways may also contribute to the mutagenesis induced by conventional chemotherapy drugs, perhaps augmenting the mutations that arise from direct DNA damage
Cultured HCN-2 (zeige HCN2 Proteine) neurons were incubated at different times with GITRL (zeige TNFSF18 Proteine) and/or TRAIL, and thereafter nucleic acid and protein expression were measured. HCN-2 (zeige HCN2 Proteine) cells do not express GITRL (zeige TNFSF18 Proteine) mRNA, but the latter is induced after treatment with TRAIL. Cells did not express the GITRL (zeige TNFSF18 Proteine) receptor GITR (zeige TNFRSF18 Proteine) mRNA, neither in control cultures, nor after treatment with TRAIL. TRAIL, when associated to GITRL (zeige TNFSF18 Proteine), exerted additive toxic effects.
OPG (zeige TNFRSF11B Proteine) and OPG (zeige TNFRSF11B Proteine)/TRAIL ratio expression were significantly increased in rheumatoid arthritis patients compared to controls (fold change = 1.79, p = 0.013 and 2.07, p = 0.030, respectively), RANKL/OPG (zeige TNFSF11 Proteine) ratio was significantly decreased (fold change = 0.50, p = 0.020). No significant differences were found between patients and controls in RANKL (zeige TNFSF11 Proteine) and TRAIL expression.
DR5 (zeige TNFRSF10B Proteine) has a dual role in death and survival signaling, which results in TRAIL resistance in cancer cells.
Dynamin (zeige DNM1 Proteine) isoforms differentially regulate the endocytosis and apoptotic signaling downstream of TRAIL-death receptor (TRAIL-DR) complexes in cancer cells. TRAIL stimulation activates ryanodine receptor (zeige RYR3 Proteine)-mediated calcium release from endoplasmic reticulum stores, leading to calcineurin-mediated dephosphorylation and activation of Dyn1 (zeige DNM1L Proteine), TRAIL-DR endocytosis, and increased resistance to TRAIL-induced apoptosis.
Isolated highly-pure population of DcR2 (zeige TNFRSF10D Proteine)-positive renal tubular epithelial cells was isolated by MACS, which was confirmed to comprise of active senescent RTECs based on the cell cycle phase.
In this study, the authors identified by gene expression profiling that microgravity induces high levels of TRAIL expression in murine preosteoclast cells in the absence of RANKL (zeige TNFSF11 Proteine) stimulation compared to ground based cultures.
Data suggest that the CXCL9 (zeige CXCL9 Proteine)-CXCR3 (zeige CXCR3 Proteine) axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation.
Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.
TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (zeige NOX4 Proteine)/eNOS (zeige NOS3 Proteine)/nitric oxide signaling.
Study reports that loss of the Opg (zeige TNFSF11 Proteine) gene results in deterioration of abdominal aortic aneurysms (AAA (zeige AAAS Proteine)), possibly through involvement of TRAIL in smooth muscle actin (SMA (zeige SMN1 Proteine))-positive cells and myofibroblasts.
PARP1 (zeige PARP1 Proteine) acts as a prominent upstream regulator of high mobility group box 1 (zeige HMGB1 Proteine)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance
Data suggest that Socs3 (suppressor of cytokine signaling 3 (zeige SOCS3 Proteine)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (zeige MAPK8 Proteine)/AP-1 (zeige JUN Proteine) transcription factor signaling.
These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (zeige HSP70 Proteine).
Data suggest forkhead box protein O1 (FoxO1 (zeige FOXO1 Proteine)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (zeige FASL Proteine) expression during follicular atresia.
The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.
xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs (zeige SSU1 Proteine), presumably owing to PKC activation, as part of the mechanism for RBC (zeige CACNA1C Proteine) switching
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, TNF-related apoptosis inducing ligand TRAIL
, chemokine tumor necrosis factor ligand superfamily member 10
, tumor necrosis factor (ligand) family, member 10
, tumor necrosis factor apoptosis-inducing ligand splice variant delta
, tumor necrosis factor ligand superfamily member 10
, TNF-related apoptosis inducing ligand
, TNF-related apoptosis-inducing ligand
, tumor necrosis factor-related apoptosis-inducing ligand
, TNF-related apoptosis-inducing ligand 1
, tumor necrosis factor related apoptosis inducing ligand 1
, tumor necrosis factor (ligand) superfamily, member 10 like 2
, tumor necrosis factor (ligand) superfamily, member 10
, tumor necrosis factor ligand 6A
, tumor necrosis factor superfamily member 10