Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Our studies suggest that although moderate levels of expression can result in partial amelioration of the hemophagocytic lymphohistiocytosis (HLH)phenotype, high levels of perforin expression per cell are required for complete correction of HLH.
Findings support an association between childhood DNA methylation (zeige HELLS Proteine) patterns in PRF1 and a record of severe respiratory syncytial virus bronchiolitis in infancy.
our data provide the first evidence of a strict link between the absence of CD28 (zeige CD28 Proteine) and the expression of perforin, which is likewise enhanced by the expression of NKG2D (zeige KLRK1 Proteine), within selected CD4 (zeige CD4 Proteine)(+) T cells from cervical cancer patients.
A girl with neurological manifestations of familial hemophagocytic lymphohistiocytosis 2 had reduced perforin 1 expression and was found to be homozygous for a mutation in PRF1 at codon 637 in exon 3 (c.673C>T p.Arg225Trp). Her non-consanguineous parents were both heterozygous carriers of this mutation.
Mutation in PRF1 gene is associated with hemophagocytic lymphohistiocytosis.
The transcriptional activation of CXCL10 (zeige CXCL10 Proteine) and CXCL11 (zeige CXCL11 Proteine) by ZNF395 (zeige ZNF395 Proteine) was abolished after inhibition of IKK (zeige CHUK Proteine) by BMS-345541, which increased the stability of ZNF395 (zeige ZNF395 Proteine). ZNF395 (zeige ZNF395 Proteine) encodes at least two motifs that mediate the enhanced degradation of ZNF395 (zeige ZNF395 Proteine) in response to IKK (zeige CHUK Proteine) activation. Thus, IKK (zeige CHUK Proteine) is required for ZNF395 (zeige ZNF395 Proteine)-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 (zeige ZNF395 Proteine) low.
Increased TIM3 (zeige HAVCR2 Proteine)+CD8 (zeige CD8A Proteine)+T cells with lower perforin and granzyme B expression and higher CD95 (zeige FAS Proteine) expression in MDS (zeige PAFAH1B1 Proteine) patients were observed.
ITP (zeige ITPA Proteine) patients displayed an increased frequency of rare missense variations of the PRF1 gene
The decreased expression of perforin in circulating CD3 (zeige CD3 Proteine)+CD8 (zeige CD8A Proteine)+ positive T cells is an important biomarker of damaged antitumor immunity in advanced lung cancer.
Letter/Case Report: recurrent episodes of macrophage activation syndrome in peripheral spondyloarthritis with monoallelic missense mutations in PRF1.
levetiracetam can still protect neurons with perforin knockout mice.
These studies indicate that CD8 (zeige CD8A Proteine)+ T cells against a single antigen can restrict Y. pseudotuberculosis colonization in a perforin-dependent manner, but ultimately are insufficient in their ability to provide sterilizing immunity and protect against death.
Furthermore, perforin production specifically by CD8 (zeige CD8A Proteine) T cells was required to cause fatal edema during experimental cerebral malaria.
Our study suggests that perforin plays a role in dopaminergic neuron loss in PD.
IL-18 (zeige IL18 Proteine)-elicited NK cell perforin responses seem to be critical for coordinating mucosal inflammation during early infection
study shows that perforin is essential to facilitate beta cell destruction in mouse models of type 1 diabetes
Released granzyme B induces DNA fragmentation in intraepithelial lymphocytes independently of Perforin
serglycin (zeige SRGN Proteine) plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin and granzyme B, whereas granzyme A (zeige GZMA Proteine) is unaffected
This suggests that LPS alters UNK cell migration and activates cytotoxic granule release.
it is proposed that Ca(2 (zeige CA2 Proteine)+) binding at the weakest affinity site triggers changes in the perforin C2 domain that facilitate its interaction with lipid membranes
It is a cytotoxic genes in the endometrium and hightly expressed in the peri (zeige PLIN1 Proteine)-implantation endometrium.
Plays a role in papillomavirus genes transcription.
, lymphocyte pore forming protein
, lymphocyte pore-forming protein
, HD gene regulatory region-binding protein 2
, HD-regulating factor 2
, Huntington's disease gene regulatory region-binding protein 2
, huntington disease gene regulatory region-binding protein 2
, papillomavirus regulatory factor 1
, papillomavirus regulatory factor PRF-1
, papillomavirus-binding factor
, perforin 1 (pore forming protein)
, pore forming protein
, perforin 1 (pore forming protein) L homeolog
, perforin 1 L homeolog