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FasL (rs763110) polymorphism is associated with the susceptibility of with intervertebral disc degeneration (IVDD). FasL (rs763110) is related to the progression of musculoskeletal degenerative diseases (MSDD) for both Caucasoid and Chinese race groups.
Localization of FasL to intra-luminal vesicles within cytolytic granules facilitates FasL trafficking to immune synapses and cytotoxic function in natural killer cells.
These data indicate that the Fas/FasL system increases pulmonary protein permeability by a direct effect on the alveolar epithelium that involves the alteration of its TJ proteins and permeability properties.
Glaucocalyxin A activates FasL and induces apoptosis through activation of the JNK pathway in human breast cancer cells.
Fasl pathway role in the myelodysplastic syndrome.
Luteolin induced apoptosis of HL-60 cells, and this was associated with c-Jun activation and histone H3 acetylation-mediated Fas/FasL expressions.
FASL polymorphisms were significantly associated with susceptibility to intervertebral disc degeneration in Chinese Han population.
our data suggest that si- and/or shRNAs with certain seed sequences present in CD95 and CD95L and the entire CD95L ORF are toxic to cancer cells.
FasL may have a role in transitional cell carcinoma of the bladder
FASLG single-nucleotide polymorphisms rs763110 and rs5030772 are involved in the pathogenesis of Idiopathic Aplastic Anemia
Evaluation of FAS/FASL polymorphisms can predict lack of response to BCG immunotherapy and prevent the loss of valuable time before such alternative treatments as early cystectomy are initiated.
results suggest that miR-21 regulates the apoptosis of keloid fibroblasts via targeting FasL, and caspase-8 and the mitochondria-mediated apoptotic signaling pathway is involved in this process.
the detailed mechanisms of FasL-Fas necroptosis can help in understanding the processes of elimination of tumor cells that have blocked apoptosis signal transduction
These results demonstrated that overexpression of ING4 can induce the apoptosis of melanoma cells and CD3+ T cells through signaling pathways such as the Fas/FasL pathway, and that ING4 gene therapy for melanoma treatment is a novel approach.
Tag7 activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
this study characterized in juvenile systemic lupus erythematosus a distinct profile from adult SLE that comprises increased sFas, sTRAIL, and reduced sFasL, notably in patients with active disease and with nephritis.
Increased FASL expression is associated with dermatofibrosarcoma protuberans.
data demonstrated that FASL-844C/T SNP was substantially associated with idiopathic azoospermia, indicating that it might be a genetic predisposing factor of idiopathic azoospermia in the Western of Iran.
platelet-derived FasL has a role in apoptosis in stroke
The authors observed differential expression of CD95(Fas) in CD27(+) B-cells from cirrhotic patients that was inversely correlated with peripheral CD27(+) B-cell frequency. They conclude that peripheral CD27(+) memory B-cells in cirrhosis exhibit increased sensitivity to Fas-induced apoptosis in an activation-dependent manner to which endotoxin contributes, associated with reduced frequency of circulating memory B-cells.
It was concluded that the Fas-FasL signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B cell lymphoma/leukemia-2 associated X upregulation.
activation of the Fas pathway and presence of FSH during in vitro maturation increased the incidence of apoptosis in cumulus cells
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL expression during follicular atresia.
FasL was not detected on fetal pig pancreatic cells but could be induced on both beta and non-beta cells when the cells were treated with IL1beta.
The expression of FAS and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported
the result indicates that the expression of FasL by chondrocytes is capable of inducing apoptosis of activated T cells
The present results may provide some insights to understand the role of Fas/FasL in the spinal cord but not motor cortex with neuronal apoptosis and neuroplasticity in monkeys subjected to hemisection spinal cord injury.
Fas/FasL signaling is critical for the survival of exhausted CD8(+) T cells during the tumor immune response.
FasL plays a crucial role in the mechanisms of blister formation
The Fas/FasL-dependent aberrant iNKT cell responses.
Autosomal Dominant Polycystic Kidney Disease patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF-beta1 than controls
The results revealed that miR181a exerted a negative regulatory effect on BMMSCinduced CD4+T lymphocyte apoptosis by regulating FasL protein expression in BMMSCs; this maybe a key mechanism underlying the development of estrogen deficiencyinduced osteoporosis.
In conclusion, these data demonstrate that murine herpesvirus 68-immortalized SL-1 cells can be recognized and controlled by specific cytotoxic T cells through CD95/CD95L-mediated apoptosis.
Both Sharpin/Fas and Sharpin/Fasl compound mutant mice developed an auto-inflammatory phenotype similar to that seen in Sharpin null mice, indicating that initiation of apoptosis by FAS signalling is likely not involved in the pathogenesis of this disease.
the analysis of mRNA level showed that disease progression is associated with significantly increased expression of FasR and/or FasL. In conclusion, our observation seems to confirm that spherical model of cancer lines is more reliable for some sophisticated analysis because of their greater resemblance to the CSCs from human CRC samples in comparison to commonly used adherent cells
study indicates FAS-FASL promoter SNPs may promote the production of cross-reactive anti-ganglioside antibodies in GBS
Report dysregulation of the Fas/FasL system occurs in an experimental animal model of HELLP syndrome.
Vitamin D could alleviate pathological changes, reduce Fas/FasL expression, and attenuate myocardial cell apoptosis in diabetic cardiomyopathy rats, which might be used as a potential effective therapy for the disease.
Our data suggest that serum sFasL may serve as an indicator of apoptotic thyroid state. sFasL may also act as a useful predictor of a clinical course in GD.
This study highlights a coordinated neurovascular development instructed by CNS macrophage-derived CD95L.
Hrd1-null B cells exhibited high Fas expression during activation and rapidly underwent Fas-mediated apoptosis, which could be largely inhibited by FasL neutralization. Fas mutation in Hrd1 KO mice abrogated the increase in B-cell AICD. We identified Hrd1 as the first E3 ubiquitin ligase of the death receptor Fas and Hrd1-mediated Fas destruction as a molecular mechanism in regulating B-cell immunity.
this study suggests that FasL gene polymorphisms in peripheral blood might be accurate in detecting cellular acute rejection following pediatric renal transplantation
CD3(+) CD8(+) NKG2D(+) T Lymphocytes Induce Apoptosis and Necroptosis in HLA-Negative Cells via FasL-Fas Interaction
this study shows that the -844T/C polymorphism in the FasL gene confers risk to hepatocellular carcinoma in Egyptian patients
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
, apoptosis (APO-1) antigen ligand 1
, apoptosis antigen ligand
, fas antigen ligand
, tumor necrosis factor (ligand) superfamily, member 6
, tumor necrosis factor ligand superfamily member 6
, APO-1 ligand
, TNF superfamily, member 6
, FAS antigen CD95
, Fas antigen ligand
, generalized lymphoproliferative disease
, Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
, CD95L protein
, Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
, Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
, Fas ligand (TNF superfamily, member 6)