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Human CYLD Protein expressed in HEK-293 Cells - ABIN2712747
Thein, Tao-Cheng, Li, Bayer, Reese, Dosemeci: CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. in PLoS ONE 2014
theses data show that CYLD regulates the magnitude of ubiquitination of several major effectors of the EGFR (zeige EGFR Proteine) pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR (zeige EGFR Proteine) complex.
Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB (zeige NFKB1 Proteine) signaling, miR (zeige MLXIP Proteine)-130b can in return sustain the persistent activation of NF-kappaB (zeige NFKB1 Proteine), which may promote the malignant progression of transitional cell carcinoma of bladder.
While previous reports have described CYLD as a regulator of DVL proteins; this data suggests the presence of a more complicated reciprocal regulatory mechanism in CML cell lines.
Thrombin (zeige F2 Proteine)-mediated MALT1 (zeige MALT1 Proteine) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
MiR (zeige MLXIP Proteine)-767 acted as a role of tumor promoter by targeting CYLD in human melanoma.
SPATA2 (zeige SPATA2 Proteine) has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (zeige RNF31 Proteine) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
The data reveal SPATA2 (zeige SPATA2 Proteine) as a high-affinity binding partner of CYLD and HOIP (zeige RNF31 Proteine), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (zeige NFKB1 Proteine) signaling.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (zeige TRAF3 Proteine) (tumor necrosis factor (zeige TNF Proteine) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (zeige TRAF3 Proteine) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (zeige STAT3 Proteine) and miR (zeige MLXIP Proteine)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 (zeige HDAC6 Proteine) axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
TLR4 (zeige TLR4 Proteine) activates CASPASE-8 (zeige CASP8 Proteine) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (zeige RNF138 Proteine)- and RIPK1 (zeige RIPK1 Proteine)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (zeige NOX4 Proteine) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (zeige MYD88 Proteine)-mediated signaling by directly interacting with MyD88 (zeige MYD88 Proteine) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (zeige MYD88 Proteine) at lysine 231.
CYLD interrupts the ERK (zeige EPHB2 Proteine)- and p38 (zeige CRK Proteine)-/AP-1 (zeige JUN Proteine) and c-Myc (zeige MYC Proteine) pathways to suppress Nrf2 (zeige NFE2L2 Proteine)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (zeige DNMT1 Proteine)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (zeige DNMT1 Proteine)-linked chains are presented.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog