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anti-Human CFLAR Antikörper:
anti-Mouse (Murine) CFLAR Antikörper:
anti-Rat (Rattus) CFLAR Antikörper:
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Human Polyclonal CFLAR Primary Antibody für ELISA, ICC - ABIN4312113
Kim, Fisher, Xu, el-Deiry: Molecular determinants of response to TRAIL in killing of normal and cancer cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2000
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Human Monoclonal CFLAR Primary Antibody für ICC, IHC - ABIN1169018
Scaffidi, Schmitz, Krammer, Peter: The role of c-FLIP in modulation of CD95-induced apoptosis. in The Journal of biological chemistry 1999
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Human Monoclonal CFLAR Primary Antibody für IP, WB - ABIN1169019
Rescigno, Piguet, Valzasina, Lens, Zubler, French, Kindler, Tschopp, Ricciardi-Castagnoli et al.: Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate ... in The Journal of experimental medicine 2000
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Human Monoclonal CFLAR Primary Antibody für FACS, IHC - ABIN1724850
Bedolla, Gong, Prihoda, Yeh, Thompson, Ghosh, Kumar: Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence. in PLoS ONE 2012
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Human Monoclonal CFLAR Primary Antibody für IHC, ELISA - ABIN1724856
Noh, Lee, Sung, Song, Kim, Woo, Kwon, Lee: CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation. in Journal of cellular biochemistry 2012
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Human Polyclonal CFLAR Primary Antibody für WB - ABIN4312104
Garimella, Gehlhaus, Dine, Pitt, Grandin, Chakka, Nau, Caplen, Lipkowitz: Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. in Breast cancer research : BCR 2014
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Human Polyclonal CFLAR Primary Antibody für ICC, ELISA - ABIN1030398
Bucur, Pennarun, Stancu, Nadler, Muraru, Bertomeu, Khosravi-Far: Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP. in Apoptosis : an international journal on programmed cell death 2013
Human Polyclonal CFLAR Primary Antibody für ICC, IF - ABIN4312114
Jones, Moskaluk, Gillenwater, Petroni, Burks, Philips, Rehm, Olazagasti, Kozower, Bao: Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancer. in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012
The knockdown of endogenous c-FLIP revealed that this protein regulates hepatitis B virus replication through two different mechanisms. (i) c-FLIP interacts with HBx and protects it from ubiquitin-dependent degradation. (ii) c-FLIP regulates the expression or stability of hepatocyte nuclear factors (HNFs), which have critical roles in HBV transcription and maintenance of hepatocytes.
Nogo-B (zeige RTN4 Antikörper) was shown to play an important negative role in apoptotic signaling through its interaction with c-FLIP in colorectal cancer cells.
Compared to normal tissues, hepatocellular carcinoma tissues had lower miR (zeige MLXIP Antikörper)-20 and higher CFLAR expression.
Investigations of underlying molecular mechanisms of TNFR1 (zeige TNFRSF1A Antikörper) signaling showed that PDF affects TNFR1 (zeige TNFRSF1A Antikörper) signaling at the proapoptotic signaling pathway by upregulation of IkappaBalpha (zeige NFKBIA Antikörper) and downregulation of cFLIPL.
c-FLIP expression was significantly decreased in organs of septic rats compared with control rats, and that c-FLIP overexpression protected HUVECs from LPS (zeige IRF6 Antikörper)+CHX-induced apoptosis in vitro.
case-control study, including 600 hepatocellular carcinoma (HCC) and 600 HBsAg positive controls without HCC, was conducted to assess the relationship between 11 tagging SNPs in CASP8, CASP10 and CFLAR and HBV-related HCC risk .These results suggest that the CASP8 -652 6N ins/del polymorphism may play a protective role in the development, progression, and survival of HBV-related HCC among the Chinese Han population.
we found that plumbagin could enhance TRAIL-induced apoptosis in Kasumi-1 cells, and the mechanisms include ROS (zeige ROS1 Antikörper)-mediated upregulation of DR5 (zeige TNFRSF10B Antikörper) expression, caspase-8 (zeige CASP8 Antikörper) activation and inhibition of cFLIP expression
Cordycepin induces apoptosis through autophagy-mediated downregulation of c-FLIPL in human non-small cell lung carcinoma cells.
High c-FLIP expression is associated with lung cancer.
miRNA-708 acts as a tumor suppressor because it negatively regulates the anti-apoptotic protein c-FLIPL and regulates the sensitivity of renal cancer cells to various apoptotic stimuli.
Deletion of c-FLIP from CD11b (zeige ITGAM Antikörper)(hi) Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis.
c-FLIP modulation of AKT activity is crucial in controlling PERK signalling and sensitivity to endoplasmic reticulum stress.
Regulatory T cells have a high apoptosis rate ex vivo correlating with low c-FLIP expression.
In conclusion, our data indicated that miR (zeige MLXIP Antikörper)-150 potentially contributes to the hepatic steatosis and insulin (zeige INS Antikörper) resistance in NAFLD (zeige TSC2 Antikörper). miR (zeige MLXIP Antikörper)-150/CFLAR pathway may be a new therapeutic strategy against NAFLD (zeige TSC2 Antikörper).
Findings establish CFLAR as a key suppressor of steatohepatitis and indicate that the development of CFLAR-peptide-mimicking drugs and the screening of small-molecular inhibitors that specifically block ASK1 (zeige MAP3K5 Antikörper) dimerization are new and feasible approaches for NASH (zeige SAMSN1 Antikörper) treatment.
knockdown of cFLIPL and induced expression of FADD (zeige FADD Antikörper) rapidly accumulate intracellular ROS (zeige ROS1 Antikörper) accompanied by JNK1 (zeige MAPK8 Antikörper) activation to substantiate apoptosis.
CASP8 (zeige CASP8 Antikörper) is present exclusively as its cleaved p43 (zeige AIMP1 Antikörper) product, bound to cFLIPL.
The generation of mouse line with Flip deficiency in cells that express cre under the CD11c (zeige ITGAX Antikörper) promoter is reported.
c-FLIPL deficiency induces the caspase (zeige CASP3 Antikörper)-mediated processing of RTN4 (zeige RTN4 Antikörper), thus affecting endoplasmic reticulum (ER) shape and coupling to mitochondria. Thus, it was concluded that c-FLIPL is a novel regulator of ER morphology and ER-mitochondria crosstalk.
Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors.
results indicate downregulation of cFLIP during structural luteal regression, suggesting that cFLIP plays a survival role in the bovine corpus luteum
Conservation of FLIP's ability to inhibit apoptosis and to downregulate NF-kappaB (zeige NFKB1 Antikörper) activation across species.
cellular-Flice like inhibitory protein (cFLIP) long form, plays an anti-apoptotic role in the granulosa cells of healthy follicles of pig ovaries [cFLIP]
Intracellular remodeling with overexpression of pig c (zeige PIGC Antikörper)-FLIP in xenograft cells may decrease the innate cellular responses against xenografts, facilitating long-term xenograft survival.
Intracellular remodeling with the overexpression of c-FLIP(S/L) in xenograft cells may avoid innate cellular attacks against xenografts and facilitate long-term xenograft survival.
Overexpression of c-FLIP in xenograft cells may prevent innate cellular attacks against xenografts opening the window of opportunity for long-term xenograft survival.
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.
, CASP8 and FADD-like apoptosis regulator
, flice/caspase-i inhibitory protein
, cellular FLICE-like inhibitory protein
, CASP8 and FADD-like apoptosis regulator-like
, FADD-like anti-apoptotic molecule
, FADD-like antiapoptotic molecule 1
, MACH-related inducer of toxicity
, caspase homolog
, caspase-eight-related protein
, caspase-like apoptosis regulatory protein
, caspase-related inducer of apoptosis
, inhibitor of FLICE
, usurpin beta
, FLICE-like inhibitory protein