anti-Caspase 8 (CASP8) Antikörper

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (zeige AMD1 Antikörper)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (zeige TP53 Antikörper)-overexpressed apoptotic embryos.

2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID Antikörper) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Results illustrate the temporal and spatial activation of caspase-8 and -3 in microglia/macrophages occurring upon ischemic stroke and suggest that the expression of these caspases could be used in neuropathological diagnostic work.

2. inhibition of TAK1 (zeige NR2C2 Antikörper) triggered two caspase 8 activation pathways through the induction of RIP1 (zeige RALBP1 Antikörper)-FADD (zeige FADD Antikörper)-caspase 8 complex as well as FLIP cleavage/degradation.

3. this study identifies a crucial role for caspase-8 in the development of allergic airway inflammation

4. Prolonged treatment of human PMNs or mice bone marrow derived neutrophils (BMDN) with nitric oxide led to enhanced reactive oxygen species generation, caspase-8/caspase-3 (zeige CASP3 Antikörper) cleavage, reduced mitochondrial membrane potential and finally cellular apoptosis.

5. caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.

6. Statistically significant increases in the expression of Fas (zeige FAS Antikörper) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (zeige DAPK1 Antikörper), Traf3 (zeige TRAF3 Antikörper), Tnsf12, Tnfrsf1A (zeige TNFRSF1A Antikörper) and Ripk1 (zeige RIPK1 Antikörper).

7. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (zeige RIPK3 Antikörper))-mediated necroptosis.

8. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

9. Data indicate that NLRC4 (zeige NLRC4 Antikörper) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (zeige IL18 Antikörper) release, and implicate Caspase-8 in NLRC4 (zeige NLRC4 Antikörper) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (zeige CASP1 Antikörper) and Caspase-8.

10. ING4 (zeige ING4 Antikörper) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (zeige FAS Antikörper)-induced apoptosis in a caspase-8-dependent pathway.

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Our findings indicate the relationship of SNP CASP8 D302H and breast cancer would not be universal but only be sensitive in some particular European countries.

2. no mutations were detected in the CASP8 gene, but we observed a frequent [32/48 (66.6%)] SNP [rs1045487] in the oral cancer samples.

3. case-control study, including 600 hepatocellular carcinoma (HCC) and 600 HBsAg positive controls without HCC, was conducted to assess the relationship between 11 tagging SNPs in CASP8, CASP10 and CFLAR and HBV-related HCC risk .These results suggest that the CASP8 -652 6N ins/del polymorphism may play a protective role in the development, progression, and survival of HBV-related HCC among the Chinese Han population.

4. High caspase-8 is not significantly associated with adverse breast cancer-specific survival. No associations were observed between caspase-8 and clinicopathological criteria.

5. we found that plumbagin could enhance TRAIL-induced apoptosis in Kasumi-1 cells, and the mechanisms include ROS (zeige ROS1 Antikörper)-mediated upregulation of DR5 (zeige TNFRSF10B Antikörper) expression, caspase-8 activation and inhibition of cFLIP (zeige CFLAR Antikörper) expression

6. this study shows that mitochondrial DNA oxidation induces imbalanced activity of NLRP3 (zeige NLRP3 Antikörper)/NLRP6 (zeige NLRP6 Antikörper) inflammasomes by activation of caspase-8 and BRCC36 (zeige BRCC3 Antikörper) in dry eye

7. Importantly, the bioinformatics analysis of microarray gene expression data derived from a set of high-grade human gliomas, shows that high Caspase-8 expression levels correlate with a worse prognosis.

8. this review describes the role of caspase-8 in the initiation of extrinsic apoptosis execution and the mechanism by which caspase-8 inhibits necroptosis

9. Data indicate that elevated levels of Polo-like kinase 3 (Plk3 (zeige PLK3 Antikörper))and pT273 caspase-8 are correlated with favorable clinical outcome in patients with anal squamous cell carcinoma (anal SCC (zeige CYP11A1 Antikörper)) treated with concomitant chemoradiotherapy (CRT (zeige SLC6A8 Antikörper)).

10. Caspase-8 binding via FADD to the receptor is an indispensable initiating step in death-inducing signaling complex formation and NF-kB activation.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (zeige CASP3 Antikörper) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (zeige CASP9 Antikörper).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (zeige STAT1 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-727 and STAT1 (zeige STAT1 Antikörper) binding to the caspase-8 promoter in cultured lung endothelial cells.

2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Antikörper), IL-6 (zeige IL6 Antikörper), IL-12p40, IL-1beta (zeige IL1B Antikörper), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (zeige BCL2L1 Antikörper).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Induction of apoptosis through targeted activation of caspase (zeige CASP3 Antikörper) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.

2. Targeted gene knockdown of TNFRSF1B (zeige TNFRSF1B Antikörper) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (zeige CASP2 Antikörper) and P53 (zeige TP53 Antikörper)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (zeige CASP3 Antikörper).

3. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.