anti-Caspase 8 (CASP8) Antikörper

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (zeige AMD1 Antikörper)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (zeige TP53 Antikörper)-overexpressed apoptotic embryos.

2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID Antikörper) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. These data demonstrate that caspase-8 functions in synovial antigen-presenting cells to regulate the response to inflammatory stimuli by controlling RIPK3 (zeige RIPK3 Antikörper) action, and this delicate balance maintains homeostasis within the joint.

2. Results illustrate the temporal and spatial activation of caspase-8 and -3 in microglia/macrophages occurring upon ischemic stroke and suggest that the expression of these caspases could be used in neuropathological diagnostic work.

3. inhibition of TAK1 (zeige NR2C2 Antikörper) triggered two caspase 8 activation pathways through the induction of RIP1 (zeige RALBP1 Antikörper)-FADD (zeige FADD Antikörper)-caspase 8 complex as well as FLIP cleavage/degradation.

4. this study identifies a crucial role for caspase-8 in the development of allergic airway inflammation

5. Prolonged treatment of human PMNs or mice bone marrow derived neutrophils (BMDN) with nitric oxide led to enhanced reactive oxygen species generation, caspase-8/caspase-3 (zeige CASP3 Antikörper) cleavage, reduced mitochondrial membrane potential and finally cellular apoptosis.

6. caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.

7. Statistically significant increases in the expression of Fas (zeige FAS Antikörper) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (zeige DAPK1 Antikörper), Traf3 (zeige TRAF3 Antikörper), Tnsf12, Tnfrsf1A (zeige TNFRSF1A Antikörper) and Ripk1 (zeige RIPK1 Antikörper).

8. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (zeige RIPK3 Antikörper))-mediated necroptosis.

9. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

10. Data indicate that NLRC4 (zeige NLRC4 Antikörper) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (zeige IL18 Antikörper) release, and implicate Caspase-8 in NLRC4 (zeige NLRC4 Antikörper) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (zeige CASP1 Antikörper) and Caspase-8.

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Caspase-3 (zeige CASP3 Antikörper) and -8 and annexin V (zeige ANXA5 Antikörper) may serve as diagnostic markers in Ovarian cancer , also explained that the decrement in control of the S phase in the cell cycle may considered one of the significant factors in the development of ovarian tumors

2. High CASP8 expression is associated with Colorectal Cancer.

3. Sleep duration is associated with plasma caspase-8. Caspase-8 independently predicts diabetes mellitus years before disease onset and modifies the effect of sleep duration on incident diabetes mellitus.

4. Caspase-8 and Caspase-3 (zeige CASP3 Antikörper) expressions in tumor tissues are novel candidate prognostic markers for colorectal cancer patients

5. Reactive oxygen species-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cells.

6. this study is the first report on reduced expression of CASP8 in breast cancer versus adjacent normal tissues.

7. The polymorphisms of CASP8, rs7608692, and haplotype AGAACAG correlated with neutropenia toxicity. The haplotype GGGGAAA was associated with thrombocytopenia toxicity. We conclude that the polymorphisms of CASP8 contribute to the prognosis of advanced lung adenocarcinoma and influence the quality of life and survival.

8. These results indicated that cMyc (zeige MYC Antikörper) and Fas (zeige FAS Antikörper) regulated the sensitivity of A549 cells to irradiation by regulating caspase8-mediated Bid (zeige BID Antikörper) activation and the subsequent association with the mitochondrial pathway of apoptosis.

9. The caspase-8/Bid (zeige BID Antikörper)/cytochrome c (zeige CYCS Antikörper) axis links signals from death receptors to mitochondrial reactive oxygen species production.

10. miR (zeige MLXIP Antikörper)-21 was elevated in osteosarcoma, and overexpression of miR (zeige MLXIP Antikörper)-21 suppressed apoptosis via targeting caspase 8.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (zeige CASP3 Antikörper) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (zeige CASP9 Antikörper).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (zeige STAT1 Antikörper) at Ser (zeige SIGLEC1 Antikörper)-727 and STAT1 (zeige STAT1 Antikörper) binding to the caspase-8 promoter in cultured lung endothelial cells.

2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Antikörper), IL-6 (zeige IL6 Antikörper), IL-12p40, IL-1beta (zeige IL1B Antikörper), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (zeige BCL2L1 Antikörper).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

1. Induction of apoptosis through targeted activation of caspase (zeige CASP3 Antikörper) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.

2. Targeted gene knockdown of TNFRSF1B (zeige TNFRSF1B Antikörper) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (zeige CASP2 Antikörper) and P53 (zeige TP53 Antikörper)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (zeige CASP3 Antikörper).

3. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.