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Rat (Rattus) Caspase 12 ELISA Kit für Sandwich ELISA - ABIN811977
Saeed, El-Naga, El-Bakly, Abdel-Rahman, Salah ElDin, El-Demerdash: Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: A mechanistic study. in Biochemical pharmacology 2015
mice ablated for caspase-12 develop spontaneous obesity and insulin resistance.
Bnip3L (zeige BNIP3L ELISA Kits) and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
Caspase-12 plays a pivotal role in CCl4 (zeige CCL4 ELISA Kits)-induced hepatic apoptosis through the activation of the downstream effector caspase-3 (zeige CASP3 ELISA Kits) directly and/or indirectly via caspase-9 (zeige CASP9 ELISA Kits) activation.
We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration.
Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin (zeige DMD ELISA Kits)-deficient mdx (zeige DMD ELISA Kits) mouse, the model for Duchenne muscular dystrophy (zeige DMD ELISA Kits).
Tauroursodeoxycholic acid intervention down-regulated GRP78 (zeige HSPA5 ELISA Kits) and CHOP (zeige DDIT3 ELISA Kits) expression and Caspase 12 activation.
Findings indicate that although caspase-12 deficiency results in enhanced pro-inflammatory and immunoregulatory cytokine levels in sera during P. yoelii 17XL infection, these responses are not essential for protection against lethal malaria infection.
caspase-12 competed with NEMO (zeige IKBKG ELISA Kits) for association with IkappaB kinase-alpha (zeige CHUK ELISA Kits)/beta, effectively preventing the formation of the IkappaB kinase (zeige CHUK ELISA Kits) complex and inhibiting downstream transcriptional activation by NF-kappaB (zeige NFKB1 ELISA Kits).
Caspase-12 was required for an effective antiviral immune response, especially for the production of type I interferons through the regulation of TRIM25 (zeige TRIM25 ELISA Kits)-mediated ubiquitination of RIG-I (zeige DDX58 ELISA Kits). .
Matrix metalloproteinase-3 (zeige MMP3 ELISA Kits) is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress
CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans
Endoplasmic reticulum stress related factor ATF6 (zeige ATF6 ELISA Kits) and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children.
We found that RNA interference-induced Caspase-12 silencing increased NOD1 (zeige NOD1 ELISA Kits), hBD1 (zeige DEFB1 ELISA Kits) and hBD2 (zeige DEFB4 ELISA Kits) expression
EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis.
Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores.
CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection.
examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product
caspase 12 has acquired deleterious mutations
Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion (zeige PRNP ELISA Kits) disorders.
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
, caspase 12 pseudogene 1
, inactive caspase-12