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anti-Mouse (Murine) Caspase 12 Antikörper:
anti-Rat (Rattus) Caspase 12 Antikörper:
anti-Human Caspase 12 Antikörper:
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Human Polyclonal Caspase 12 Primary Antibody für IHC (p), WB - ABIN3042658
Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect. in PLoS ONE 2011
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mice ablated for caspase-12 develop spontaneous obesity and insulin resistance.
Bnip3L (zeige BNIP3L Antikörper) and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
Caspase-12 plays a pivotal role in CCl4 (zeige CCL4 Antikörper)-induced hepatic apoptosis through the activation of the downstream effector caspase-3 (zeige CASP3 Antikörper) directly and/or indirectly via caspase-9 (zeige CASP9 Antikörper) activation.
We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration.
Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin (zeige DMD Antikörper)-deficient mdx (zeige DMD Antikörper) mouse, the model for Duchenne muscular dystrophy (zeige DMD Antikörper).
Tauroursodeoxycholic acid intervention down-regulated GRP78 (zeige HSPA5 Antikörper) and CHOP (zeige DDIT3 Antikörper) expression and Caspase 12 activation.
Findings indicate that although caspase-12 deficiency results in enhanced pro-inflammatory and immunoregulatory cytokine levels in sera during P. yoelii 17XL infection, these responses are not essential for protection against lethal malaria infection.
caspase-12 competed with NEMO (zeige IKBKG Antikörper) for association with IkappaB kinase-alpha (zeige CHUK Antikörper)/beta, effectively preventing the formation of the IkappaB kinase (zeige CHUK Antikörper) complex and inhibiting downstream transcriptional activation by NF-kappaB (zeige NFKB1 Antikörper).
Caspase-12 was required for an effective antiviral immune response, especially for the production of type I interferons through the regulation of TRIM25 (zeige TRIM25 Antikörper)-mediated ubiquitination of RIG-I (zeige DDX58 Antikörper). .
Matrix metalloproteinase-3 (zeige MMP3 Antikörper) is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress
Piezo1 (zeige PIEZO1 Antikörper) plays an important role in the apoptosis of human osteoarthritis-derived chondrocytes through a caspase-12-dependent pathway.
study indicated the potential effect of Casp12 was on the activation of NF-kappaB (zeige NFKB1 Antikörper) by the degradation of IkappaBalpha (zeige NFKBIA Antikörper) in NPC (zeige NPC1 Antikörper) cells.
CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans
Endoplasmic reticulum stress related factor ATF6 (zeige ATF6 Antikörper) and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children.
We found that RNA interference-induced Caspase-12 silencing increased NOD1 (zeige NOD1 Antikörper), hBD1 (zeige DEFB1 Antikörper) and hBD2 (zeige DEFB4 Antikörper) expression
EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis.
Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores.
CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection.
examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
, caspase 12 pseudogene 1
, inactive caspase-12