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Cheng, van de Veerdonk, Lenardon, Stoffels, Plantinga, Smeekens, Rizzetto, Mukaremera, Preechasuth, Cavalieri, Kanneganti, van der Meer, Kullberg, Joosten, Gow, Netea: The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. in Journal of leukocyte biology 2011
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Abais, Xia, Li, Chen, Conley, Gehr, Boini, Li: Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia. in The Journal of biological chemistry 2014
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Mouse (Murine) Caspase 1 ELISA Kit für Sandwich ELISA - ABIN1168983
Miyazaki, Mihara, Inata, Sasaki, Tominaga, Yakura, Ishida, Fukushima, Inoue: Pharmacologic inhibition of IκB kinase activates immediate hypersensitivity reactions in mice. in The American journal of pathology 2013
Human Caspase 1 ELISA Kit für Sandwich ELISA - ABIN417148
DIppolito, Tersigni, Marana, Di Nicuolo, Gaglione, Rossi, Castellani, Scambia, Di Simone: Inflammosome in the human endometrium: further step in the evaluation of the "maternal side". in Fertility and sterility 2016
Rat (Rattus) Caspase 1 ELISA Kit für Sandwich ELISA - ABIN432222
Ragab, Abdallah, El-Abhar: Cilostazol renoprotective effect: modulation of PPAR-?, NGAL, KIM-1 and IL-18 underlies its novel effect in a model of ischemia-reperfusion. in PLoS ONE 2014
Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation
sickle red blood cell induced TLR9 (zeige TLR9 ELISA Kits), NLRP3 (zeige NLRP3 ELISA Kits), Caspase-1, IL-1beta (zeige IL1B ELISA Kits) and IL-18 (zeige IL18 ELISA Kits) expression and induced IL-1beta (zeige IL1B ELISA Kits), LTB4 (zeige PTGR1 ELISA Kits) and nitrite production in PBMC cultures.
Data show that the serine protease inhibitor B9 (serpinB9 (zeige SERPINB9 ELISA Kits)) mediated caspase-1 inhibition regulates IL-1beta (zeige IL1B ELISA Kits) release in monocytes.
study uncovers a novel mechanism of G9A (zeige EHMT2 ELISA Kits) promoting tumor cell growth and invasion by silencing CASP1, and implies that G9A (zeige EHMT2 ELISA Kits) may serve as a therapeutic target in treating Non-small-cell lung cancer.
Caspase-1 polymorphisms may play a role in Chagas cardiomyopathy development and could serve as markers to identify individuals at higher risk for priority treatment.
besides its role in the inhibition of the NF-kappaB (zeige NFKB1 ELISA Kits) pathway, NLRC3 (zeige NLRC3 ELISA Kits) interferes with the assembly and activity of the NALP3 (zeige NLRP3 ELISA Kits) inflammasome complex by competing with ASC (zeige PYCARD ELISA Kits) for pro-caspase-1 binding
Data, including data from studies using recombinant fusion forms of GSDMD (gasdermin D (zeige GSDMD ELISA Kits)), suggest that GSDMD (zeige GSDMD ELISA Kits) participates in inflammasome-dependent pyroptosis of macrophages in response to various stimuli; this mechanism involves proteolysis of GSDMD (zeige GSDMD ELISA Kits) by caspase-1 and caspase-11 (zeige CASP4 ELISA Kits).
Proteases caspase-1 and caspase-8 (zeige CASP8 ELISA Kits) have redundant roles in cleaving IL-1beta (zeige IL1B ELISA Kits) and promoting osteomyelitis. [review]
Patients with NLRP1 (zeige NLRP1 ELISA Kits)-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic CASP1.
The biochemical function of NLPR3 inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (zeige IL1B ELISA Kits) and IL-18 (zeige IL18 ELISA Kits) and the induction of pyroptosis, a form of cell death. (Review)
Adult neural stem cells (ANSCs) expressed NLRP3 (zeige NLRP3 ELISA Kits)-containing inflammasome and alpha-syn activated both TLR4 (zeige TLR4 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) and NLRP3 (zeige NLRP3 ELISA Kits)/caspase-1 signals in ANSCs.
dimerized or endogenous caspase-8 (zeige CASP8 ELISA Kits) can also directly cleave IL-1beta (zeige IL1B ELISA Kits) into its biologically active form, in the absence of canonical inflammasome components.
Report direct role of pleural cells in the pathogenesis of bleomycin-induced pulmonary fibrosis via caspase-1/IL-1beta (zeige IL1B ELISA Kits) pathway.
caspase-1-/- mice exhibited resistance to indomethacin-induced small intestinal damage
data provide evidence that the NLRC4 (zeige NLRC4 ELISA Kits) inflammasome contributes to resistance through regulation of caspase-1, IL-1beta (zeige IL1B ELISA Kits) and IL-18 (zeige IL18 ELISA Kits) in a CD11blowLy6Glow population of cells
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4 (zeige TLR4 ELISA Kits), which activates Nlrp3 (zeige NLRP3 ELISA Kits), and subsequently induces caspase-1 activation.
The most well-known function of active caspase-1 is to cleave the proforms of inflammatory cytokines IL-1beta (zeige IL1B ELISA Kits) and -18 into their active forms in response to inflammatory stimuli in immune cells. Caspase-1 has multiple functions in addition to this cytokine maturation role. It is at the center of many cell responses to stress and inflammation not just in immune cells but in other cell types, such as epithelia. Review.
Findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity.
Inflammasome NLRP3 (zeige NLRP3 ELISA Kits)-caspase-1-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.
Src kinase (zeige CSK ELISA Kits) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
endometrial expression of CASP1 and IL18 (zeige IL18 ELISA Kits) associated with pregnancy establishment; alteration of CASP1 and IL18 (zeige IL18 ELISA Kits) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
drICE (zeige CASP3 ELISA Kits) and dcp-1 (zeige ACE ELISA Kits) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (zeige CASP3 ELISA Kits) but not dcp-1 (zeige ACE ELISA Kits), but required drICE (zeige CASP3 ELISA Kits) and dcp-1 (zeige ACE ELISA Kits) when drICE (zeige CASP3 ELISA Kits) activity was reduced via hypomorphic mutation.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (zeige ACE ELISA Kits), and ice
Autophagy suppresses Dcp-1 (zeige ACE ELISA Kits)-mediated apoptotic cell death, whereas Dcp-1 (zeige ACE ELISA Kits) positively regulates autophagy, possibly through feedback regulation.
novel characteristic morphological features of egg chambers lacking both dcp-1 (zeige ACE ELISA Kits) and pita functions in the germline cells; suggested an essential role of dcp-1 (zeige ACE ELISA Kits) and/or pita during mid-oogenesis
A double-mutant analysis between drICE (zeige CASP3 ELISA Kits) and death caspase-1 (dcp-1), another effector caspase (zeige CASP3 ELISA Kits), reveals that some cells (type I) strictly require drICE (zeige CASP3 ELISA Kits) for apoptosis, whereas other cells (type II) require either drICE (zeige CASP3 ELISA Kits) or dcp-1 (zeige ACE ELISA Kits).
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein (zeige BIRC2 ELISA Kits) Bruce (zeige BIRC6 ELISA Kits) function to regulate both autophagy and starvation-induced cell death in Drosophila.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (zeige ACE ELISA Kits), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Bombyx mori caspase-1 plays an important role during baculovirus infection.
cBm-IAP1 (zeige BIRC3 ELISA Kits) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.
Activation of Atg5 (zeige ATG5 ELISA Kits), AIF (zeige AIFM1 ELISA Kits) and caspase (zeige CASP3 ELISA Kits) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
CASP1 nirs variant 1
, IL-1 beta-converting enzyme
, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
, interleukin 1, beta, convertase
, interleukin 1-B converting enzyme
, IL-1B converting enzyme
, interleukin 1 beta-converting enzyme
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, Interleukin 1beta converting enzyme
, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
, interleukin-1 beta converting enzyme
, caspase-1/caspase-4 hybrid
, caspase 1
, death caspase-1