anti-BID (BID) Antikörper

Human BH3 Interacting Domain Death Agonist (BID) Interaktionspartner

1. results suggest that histone modifications in the promoter region of miR (zeige MLXIP Antikörper)-500a may be responsible for the increased expression of miR (zeige MLXIP Antikörper)-500a in Hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)), which promotes cancer progression by targeting BID, indicating that miR (zeige MLXIP Antikörper)-500a may be a potential prognostic predictor and therapeutic target for HCC (zeige FAM126A Antikörper) patients.

2. The caspase-8 (zeige CASP8 Antikörper)/Bid/cytochrome c (zeige CYCS Antikörper) axis links signals from death receptors to mitochondrial reactive oxygen species production.

3. administration of SMAC (zeige DIABLO Antikörper) or BH3 mimetics following short-term paclitaxel treatment could be an effective therapeutic strategy for TNBC, while only BH3-mimetics could effectively overcome long-term paclitaxel resistance

4. caspase-10 (zeige CASP10 Antikörper) was dispensable for enhancement of cisplatin/LA-12 and TRAIL combination-induced cell death and stimulation of Bid cleavage

5. an oligomeric arrangement of Bid, Bax (zeige BAX Antikörper), and possibly other members of the Bcl-2 (zeige BCL2 Antikörper) family of proteins that form a self-propagating network that permeabilizes the outer-mitochondrial membrane.

6. Combined therapy with Seliciclib((R)) and Belinostat((R)) results in eradication of non-small cell lung cancer via apoptosis induction and BID activation.

7. Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers.

8. The adenovirus-mediated truncated Bid overexpression induced by the Cre/LoxP system can effectively eliminate CD133+ ovarian cancer stem cells, representing a novel therapeutic strategy for the treatment of ovarian cancer.

9. MiR (zeige MLXIP Antikörper)-20a-directed regulation of BID in colorectal cancer.

10. the results establish that cleavage by caspase 8 (zeige CASP8 Antikörper) and the subsequent association with the outer mitochondrial membrane are two critical events that activate Bid during death receptor-mediated apoptosis.

Mouse (Murine) BH3 Interacting Domain Death Agonist (BID) Interaktionspartner

1. we show that BID is an important regulator downstream of FAS (zeige FAS Antikörper) in mouse neutrophils. Loss of BID significantly delays FASL (zeige FASL Antikörper)-cell death and partially counteracts the switch from apoptosis to necroptosis when caspases are blocked.

2. Study exposes BID as the molecular link between the previously separated pathways of oxidative stress signaling by merging the death pathways of ferroptosis and oxytosis at the level of mitochondria, i.e. the crucial point of decision for neuronal function and survival.

3. Cleaved Bid did not permeabilize the membrane, but lowered the membrane breakthrough force.

4. toxic reactive oxygen species levels in Mll5 (zeige MLL5 Antikörper)(-/-) mice are critically dependent on type 1 interferon (IFN-1) signaling, which triggers mitochondrial accumulation of full-length Bid.

5. In the present study, we identified the proapoptotic Bcl-2 (zeige BCL2 Antikörper) family protein Bid as a positive regulator of mutant SOD1 (zeige SOD1 Antikörper)-induced TLR-nuclear factor-kappaB (NF-kappaB (zeige NFKB1 Antikörper)) signaling in microglia.

6. ATM (zeige ATM Antikörper)-BID-MTCH2 (zeige MTCH2 Antikörper) pathway that we have identified plays a critical role in the DDR (zeige DDR1 Antikörper) via regulation of mitochondrial metabolism.

7. DRP1 (zeige CRMP1 Antikörper)-dependent apoptotic mitochondrial fission occurs independently of BAX (zeige BAX Antikörper), BAK (zeige BAK1 Antikörper) and APAF1 (zeige APAF1 Antikörper) to amplify cell death by BID and oxidative stress.

8. A phosphorylation-deficient mutant of BID, MTCH2 (zeige MTCH2 Antikörper)'s ligand, induces an increase in OXPHOS, but with higher ROS (zeige ROS1 Antikörper) and reduced ATP levels than Mtch2 (zeige MTCH2 Antikörper) loss, and is associated with hypersensitivity to irradiation.

9. Motifs of VDAC2 (zeige VDAC2 Antikörper) required for mitochondrial Bak (zeige BAK1 Antikörper) import and tBid-induced apoptosis.

10. BID protein suppresses p38 (zeige CRK Antikörper) activity and induce malignant cell transformation of hepatocytes.

Zebrafish BH3 Interacting Domain Death Agonist (BID) Interaktionspartner

1. Stage-specific expression of TNFalpha (zeige TNF Antikörper) regulates bad/bid-mediated apoptosis and RIP1 (zeige RALBP1 Antikörper)/ROS (zeige ROS1 Antikörper)-mediated secondary necrosis in Birnavirus-infected fish cells.

Pig (Porcine) BH3 Interacting Domain Death Agonist (BID) Interaktionspartner

1. Bid and Bax (zeige BAX Antikörper) are signal transduction factors in granulosa cells and play proapoptotic roles.

Xenopus laevis BH3 Interacting Domain Death Agonist (BID) Interaktionspartner

1. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (zeige CASP3 Antikörper)-dependent Proteolysis of JNK1 (zeige MAPK8 Antikörper)-2 and Bid.

2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BID and Caspases-2 and -8

3. Here, we identified and characterized the Xenopus homologs of caspase-10 (zeige CASP10 Antikörper) (xCaspase-10beta), a novel initiator caspase (zeige CASP3 Antikörper), and Bid (xBid), a BH3-only (zeige BBC3 Antikörper) molecule of the Bcl-2 (zeige BCL2 Antikörper) family involved in both the extrinsic and intrinsic pathways.

4. diubiquitylation is a specific feature of xBid.