APEX2 Produkte
(APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
Kategorien
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
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Ausgewählte APEX2 Kategorien
APEX2 Antikörper
High quality antibodies with extensive validation data.
APEX2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene APEX2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF, FACS, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN652924
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (2)
Kat. Nr.
ABIN525954
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, FACS, IF/ICC
Validierungen
- (3)
Kat. Nr.
ABIN3003990
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene APEX2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1130230
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1130231
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene APEX2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3089223
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3135636
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2714790
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren APEX2 Produkten
: "Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets." in: Molecular cell, Vol. 73, Issue 5, pp. 885-899.e6, (2019) (PubMed).: "Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1." in: The Journal of biological chemistry, Vol. 287, Issue 35, pp. 29801-14, (2012) (PubMed).
: "Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen." in: Nucleic acids research, Vol. 29, Issue 11, pp. 2349-60, (2001) (PubMed).
Synonyme und alternative Namen zu APEX2
apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2), apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2), APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2), apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L), APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2), apurinic/apyrimidinic endonuclease 2 (Apex2), apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2), APE2, ape2, APEXL2, apexl2, C430040P13Rik, XTH2, xth2, zgc:55889Bezeichner auf Proteinebene für APEX2
- AP endonuclease 2
- AP endonuclease XTH2
- DNA-(apurinic or apyrimidinic site) lyase 2
- apurinic/apyrimidinic endonuclease-like 2
- APEX nuclease 2
- apurinic-apyrimidinic endonuclease 2
- APEX nuclease (apurinic/apyrimidinic endonuclease) 2
- DNA-(apurinic or apyrimidinic site) lyase 2-like
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