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Glycogen Synthase 1 Antikörper (pSer641)

Der Kaninchen Polyklonal Anti-Glycogen Synthase 1-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, Glycogen Synthase 1 in Proben von Human und Maus zu detektieren.
Rockland
Produktnummer ABIN99926
Hersteller Produkt- Nr.: 600-401-415

Kurzübersicht für Glycogen Synthase 1 Antikörper (pSer641) (ABIN99926)

Target

Alle Glycogen Synthase 1 (GYS1) Antikörper anzeigen
Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Reaktivität

  • 62
  • 38
  • 31
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 61
  • 2
Kaninchen

Klonalität

  • 46
  • 17
Polyklonal

Konjugat

  • 42
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
Dieser Glycogen Synthase 1 Antikörper ist unkonjugiert

Applikation

  • 42
  • 27
  • 16
  • 12
  • 9
  • 8
  • 6
  • 5
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 17
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer641

    Hersteller Produkt- Nr.

    600-401-415

    Hersteller

    Rockland

    Verwendungszweck

    Glycogen Synthase 1 phospho S641 Antibody

    Kreuzreaktivität (Details)

    Phospho Glycogen Synthase pS641 antibody is directed against human muscle glycogen synthase.

    Produktmerkmale

    Synonyms: rabbit anti-muscle glycogen synthase pS641 antibody, rabbit anti-glycogen synthase pS641 antibody, Glycogen antibody, Glycogen synthase 1 (muscle) antibody, Glycogen synthase 1 antibody, Glycogen synthase1 antibody, GYS 1 antibody, GYS-1 antibody, GYS1 antibody, Starch synthase muscle antibody

    Aufreinigung

    The product was affinity purified from monospecific antiserum by immunoaffinity purification.

    Sterilität

    Sterile filtered

    Immunogen

    Immunogen: Human Muscle Glycogen Synthase phospho peptide corresponding to a S641 region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).

    Immunogen Type: Conjugated Peptide

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry Dilution: 1:1,000 - 1:5,000

    Application Note: This phospho specific polyclonal antibody was tested by immunoblotting, immunohistochemistry, and ELISA.  By ELISA the antibody was found to be reactive with the phosphorylated form of the immunizing peptide and minimally reactive with the non-phosphorylated form of the immunizing peptide.   Immunoblotting will detect human and mouse muscle glycogen synthase.  Although not tested, this antibody is likely functional in immunoprecipitation.

    Western Blot Dilution: 1:1,000 - 1:10,000

    ELISA Dilution: 1:20,000 - 1:60,000

    Other: User Optimized

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1.0 mg/mL

    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store Phospho GYS Antibody at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Target

    Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

    Andere Bezeichnung

    GYS1

    Hintergrund

    Background: Anti-Glycogen synthase 1 pS641 is validated by IHC, Western Blot and ELISA. Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units.  Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000.  GS is subject to regulation through both allosteric and covalent modification and occurs in two forms:  the phosphorylated inactive form, and the dephosphorylated active form.  GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3b that mainly functions to phosphorylate muscle glycogen synthase.  This antibody is specific for the phosphorylated form of GS at S641.   Phosphorylation of GS at S641 has been associated with Antiphospholipid Antibody Syndrome.

    Gen-ID

    2997

    UniProt

    P13807

    Pathways

    PI3K-Akt Signalweg, AMPK Signaling, Cellular Glucan Metabolic Process
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