PAI1 Antikörper

Produktnummer ABIN969566

Der Maus Monoklonal Anti-PAI1-Antikörper wurde für IHC, ELISA und FACS validiert. Er ist geeignet, PAI1 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für PAI1 Antikörper (ABIN969566)

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAI1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Klon: 1D5

Produktdetails anti-PAI1 Antikörper

Verwendungszweck: SERPINE1 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human SERPINE1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PAI1 Antikörper (ABIN969566)

Oh, Olman, Benveniste: "CXCL12-mediated induction of plasminogen activator inhibitor-1 expression in human CXCR4 positive astroglioma cells." in: Biological & pharmaceutical bulletin, Vol. 32, Issue 4, pp. 573-7, (2009) (PubMed).

Zee, Bubes, Shrivastava, Ridker, Glynn: "Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach." in: Clinica chimica acta; international journal of clinical chemistry, Vol. 402, Issue 1-2, pp. 189-92, (2009) (PubMed).

Details zu PAI1

Target: PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))

Andere Bezeichnung: SERPINE1

Hintergrund: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 45 kDa

UniProt: P05121

Pathways: p53 Signalweg, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagie, Smooth Muscle Cell Migration