CCL2 Antikörper

Produktnummer ABIN969505

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CCL2 in WB, IHC, ELISA, ICC und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Affe und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für CCL2 Antikörper (ABIN969505)

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reaktivität: Human, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 2D8

Produktdetails anti-CCL2 Antikörper

Verwendungszweck: CCL2 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CCL2 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-CCL2 Antikörper (ABIN969505)

Reine, Vuong, Rutkovskiy, Meen, Vaage, Jenssen, Kolset: "Serglycin in Quiescent and Proliferating Primary Endothelial Cells." in: PLoS ONE, Vol. 10, Issue 12, pp. e0145584, (2015) (PubMed).

Semple, Kossmann, Morganti-Kossmann: "Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 30, Issue 3, pp. 459-73, (2010) (PubMed).

Details zu CCL2

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Andere Bezeichnung: CCL2

Hintergrund: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Molekulargewicht: 11 kDa

Gen-ID: 6347

UniProt: P13500

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion