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PRTN3 Antikörper

Dieses Anti-PRTN3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PRTN3 in ELISA. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.
Produktnummer ABIN969498

Kurzübersicht für PRTN3 Antikörper (ABIN969498)

Target

Alle PRTN3 Antikörper anzeigen
PRTN3 (Proteinase 3 (PRTN3))

Reaktivität

  • 67
  • 14
  • 10
  • 1
  • 1
  • 1
Human

Wirt

  • 58
  • 24
  • 1
  • 1
  • 1
Maus

Klonalität

  • 62
  • 23
Monoklonal

Konjugat

  • 55
  • 10
  • 7
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PRTN3 Antikörper ist unkonjugiert

Applikation

  • 63
  • 35
  • 23
  • 19
  • 14
  • 12
  • 7
  • 6
  • 5
  • 5
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
ELISA

Klon

3B4
  • Verwendungszweck

    Proteinase 3 Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.

    Isotyp

    IgG2b
  • Applikationshinweise

    ELISA: 1/10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Kantari, Pederzoli-Ribeil, Amir-Moazami, Gausson-Dorey, Moura, Lecomte, Benhamou, Witko-Sarsat: "Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis." in: Blood, Vol. 110, Issue 12, pp. 4086-95, (2007) (PubMed).

    Abdgawad, Hellmark, Gunnarsson, Westman, Segelmark: "Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism." in: Clinical and experimental immunology, Vol. 145, Issue 1, pp. 63-70, (2006) (PubMed).

  • Target

    PRTN3 (Proteinase 3 (PRTN3))

    Andere Bezeichnung

    Proteinase 3

    Hintergrund

    Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

    Molekulargewicht

    28 kDa

    Gen-ID

    5657

    UniProt

    P24158
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