NK2 Homeobox 5 Antikörper

Produktnummer ABIN969487

Produktdetails anti-NK2 Homeobox 5 Antikörper

Target: NK2 Homeobox 5 (NKX2-5)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NK2 Homeobox 5 Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: NKX2.5 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human NKX2.5 expressed in E. Coli.

Klon: 2E1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-NK2 Homeobox 5 Antikörper (ABIN969487)

Brewer, Alexandrovich, Mjaatvedt, Shah, Patient, Pizzey: "GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis." in: Stem cells and development, Vol. 14, Issue 4, pp. 425-39, (2005) (PubMed).

Ikeda, Hiroi, Hosoda, Utsunomiya, Matsuo, Ito, Inoue, Sumiyoshi, Takano, Nagai, Komuro: "Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 66, Issue 6, pp. 561-3, (2002) (PubMed).

Details zu NK2 Homeobox 5

Target: NK2 Homeobox 5 (NKX2-5)

Andere Bezeichnung: NKX2.5 (NKX2-5 Produkte)

Hintergrund: NKX2.5: NK2 transcription factor related, locus 5 (Drosophila), also known as CSX. It is a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 35 kDa

Gen-ID: 1482

UniProt: P52952

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development