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TYK2 Antikörper
This anti-TYK2 antibody (ABIN969448) is a Mouse Monoclonal antibody detecting TYK2 in ELISA. Suitable for Human.
Quick Overview for TYK2 Antikörper (ABIN969448)
Target
Alle TYK2 Antikörper anzeigen
TYK2
(Tyrosine Kinase 2 (TYK2))
Reaktivität
Alle Reaktivitäten für TYK2 Antikörper
Human
Wirt
Alle Wirte für TYK2 Antikörper
Maus
Klonalität
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Monoklonal
Konjugat
Alle Konjugate für TYK2 Antikörper
Dieser TYK2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für TYK2 Antikörper
ELISA
Klon
8G8B3
Produktdetails anti-TYK2 Antikörper
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Verwendungszweck
Tyk2 Antibody
Aufreinigung
Ascitic fluid
Immunogen
Purified recombinant fragment of Tyk2 expressed in E. Coli.
Isotyp
IgG1
Alternativen
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Anwendungsinformationen
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Applikationshinweise
ELISA: 1/10000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Referenzen für anti-TYK2 Antikörper (ABIN969448)
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Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap : "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 176 , Issue 12 , pp. 7263-71 , (2006 ) (PubMed ).
Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto : "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 170 , Issue 2 , pp. 1077-83 , (2003 ) (PubMed ).
Details zu TYK2
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Target
TYK2
(Tyrosine Kinase 2 (TYK2))
Andere Bezeichnung
Tyk2
Hintergrund
Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
Gen-ID
7297
UniProt
P29597
Pathways
JAK-STAT Signalweg , Hepatitis C
Zuletzt angesehen
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