Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

TYK2 Antikörper

This anti-TYK2 antibody (ABIN969448) is a Mouse Monoclonal antibody detecting TYK2 in ELISA. Suitable for Human.
Produktnummer ABIN969448

Quick Overview for TYK2 Antikörper (ABIN969448)

Target

Alle TYK2 Antikörper anzeigen
TYK2 (Tyrosine Kinase 2 (TYK2))

Reaktivität

  • 87
  • 36
  • 27
  • 4
  • 1
  • 1
  • 1
Human

Wirt

  • 77
  • 12
Maus

Klonalität

  • 77
  • 13
Monoklonal

Konjugat

  • 46
  • 5
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TYK2 Antikörper ist unkonjugiert

Applikation

  • 71
  • 34
  • 21
  • 13
  • 13
  • 13
  • 12
  • 11
  • 8
  • 5
  • 2
  • 1
ELISA

Klon

8G8B3
  • Verwendungszweck

    Tyk2 Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of Tyk2 expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).

    Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).

  • Target

    TYK2 (Tyrosine Kinase 2 (TYK2))

    Andere Bezeichnung

    Tyk2

    Hintergrund

    Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.

    Gen-ID

    7297

    UniProt

    P29597

    Pathways

    JAK-STAT Signalweg, Hepatitis C
Sie sind hier:
Chat with us!