PRKAA1 Antikörper

Produktnummer ABIN969364

Dieses Maus Monoklonal-Antikörper erkennt spezifisch PRKAA1 in WB, IHC, ELISA, FACS und ICC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Affe und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für PRKAA1 Antikörper (ABIN969364)

Target: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRKAA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 2B7

Produktdetails anti-PRKAA1 Antikörper

Verwendungszweck: PRKAA1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human PRKAA1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PRKAA1 Antikörper (ABIN969364)

Pan, Yang, Cao, Song, Wallin, Kivlin, Lu, Hu, Di, Wan: "AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells." in: Oncology reports, Vol. 20, Issue 6, pp. 1553-9, (2008) (PubMed).

Egawa, Kamata, Kushiyama, Sakoda, Fujishiro, Horike, Yoneda, Nakatsu, Ying, Jun, Tsuchiya, Takata, Kurihara, Asano: "Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells." in: Placenta, Vol. 29, Issue 12, pp. 1003-8, (2008) (PubMed).

Details zu PRKAA1

Target: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Andere Bezeichnung: PRKAA1

Hintergrund: The protein belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Molekulargewicht: 64 kDa

Gen-ID: 5562

UniProt: Q13131

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt