NCOA3 Antikörper (AA 1-200)

Produktnummer ABIN969309

Produktdetails anti-NCOA3 Antikörper

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Bindungsspezifität: AA 1-200

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NCOA3 Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: NCOA3 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of NCOA3 (aa1-200) expressed in E. Coli.

Klon: 2C11B12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-NCOA3 Antikörper (ABIN969309)

Rangel, Torabian, Shaikh, Nosrati, Baehner, Haqq, Leong, Miller, Sagebiel, Kashani-Sabet: "Prognostic significance of nuclear receptor coactivator-3 overexpression in primary cutaneous melanoma." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 24, Issue 28, pp. 4565-9, (2006) (PubMed).

Zheng, Wu, Smith, OMalley: "Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor." in: Molecular and cellular biology, Vol. 25, Issue 18, pp. 8273-84, (2005) (PubMed).

Details zu NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Andere Bezeichnung: NCOA3 (NCOA3 Produkte)

Hintergrund: NCOA3: nuclear receptor coactivator 3. The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

UniProt: Q9Y6Q9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha