NCOA3 Antikörper (N-Term)

Produktnummer ABIN1881566

Es sind 4+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-NCOA3 Antikörper wird verwendet zum Nachweis von NCOA3 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für NCOA3 Antikörper (N-Term) (ABIN1881566)

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCOA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41497

Produktdetails anti-NCOA3 Antikörper

Bindungsspezifität: AA 344-372, N-Term

Homologie: Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NCOA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-372 amino acids from the N-terminal region of human NCOA3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-NCOA3 Antikörper (ABIN1881566)

Cai, Shames, Raso, Xie, Kim, Pollack, Girard, Sullivan, Gao, Peyton, Nanjundan, Byers, Heymach, Mills, Gazdar, Wistuba, Kodadek, Minna: "Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation." in: Cancer research, Vol. 70, Issue 16, pp. 6477-85, (2010) (PubMed).

Kovanen, Saarikoski, Haukka, Pirkola, Aromaa, Lönnqvist, Partonen: "Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption." in: Alcohol and alcoholism (Oxford, Oxfordshire), Vol. 45, Issue 4, pp. 303-11, (2010) (PubMed).

Karmakar, Gao, Pace, Oesterreich, Smith: "Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 6, pp. 1187-202, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Details zu NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Andere Bezeichnung: NCOA3

Hintergrund: The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Molekulargewicht: 155293

NCBI Accession: NP_001167559, NP_006525, NP_858045

UniProt: Q9Y6Q9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha