MYL3/CMLC1 Antikörper

Produktnummer ABIN969303

Zitiert in 2+ Publikationen. Der Maus Monoklonal anti-MYL3/CMLC1 Antikörper (Klon 3F8) (ABIN969303) detektiert spezifisch MYL3/CMLC1 in WB, IHC und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MYL3/CMLC1 Antikörper (ABIN969303)

Target: MYL3/CMLC1 (MYL3) (Myosin, Light Chain 3 (MYL3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MYL3/CMLC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon: 3F8

Produktdetails anti-MYL3/CMLC1 Antikörper

Verwendungszweck: MYL3 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of MYL3 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MYL3/CMLC1 Antikörper (ABIN969303)

Haase, Dobbernack, Tünnemann, Karczewski, Cardoso, Petzhold, Schlegel, Lutter, Pierschalek, Behlke, Morano: "Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 7, pp. 865-73, (2006) (PubMed).

Xie, Huang, Huang, Zhou, Gong: "The functional domains of human ventricular myosin light chain 1." in: Biophysical chemistry, Vol. 106, Issue 1, pp. 57-66, (2003) (PubMed).

Details zu MYL3/CMLC1

Target: MYL3/CMLC1 (MYL3) (Myosin, Light Chain 3 (MYL3))

Andere Bezeichnung: MYL3

Hintergrund: Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.

Molekulargewicht: 22 kDa

Gen-ID: 4634

UniProt: P08590