IL-2 Antikörper

Produktnummer ABIN969214

Dieses Maus Monoklonal-Antikörper erkennt spezifisch IL-2 in ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für IL-2 Antikörper (ABIN969214)

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-2 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 8D5

Produktdetails anti-IL-2 Antikörper

Verwendungszweck: IL-2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of IL2 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-IL-2 Antikörper (ABIN969214)

Das, Levine: "TGF-beta inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 3, pp. 1490-8, (2008) (PubMed).

Lesniewski, Haviernik, Weitzel, Kadereit, Kozik, Fanning, Yang, Hegerfeldt, Finney, Ratajczak, Greco, Paul, Maciejewski, Laughlin: "Regulation of IL-2 expression by transcription factor BACH2 in umbilical cord blood CD4+ T cells." in: Leukemia, Vol. 22, Issue 12, pp. 2201-7, (2008) (PubMed).

Details zu IL-2

Target: IL-2 (IL2) (Interleukin 2 (IL2))

Andere Bezeichnung: IL-2

Hintergrund: IL-2: interleukin-2. Entrez Protein NP_000577. It is a 17.6 kDa secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Molekulargewicht: 17.6 kDa

Gen-ID: 3558

UniProt: P60568

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation