GSTM1 Antikörper

Produktnummer ABIN969180

Dieses Anti-GSTM1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von GSTM1 in WB, IHC, ELISA und FACS. Geeignet für Human und Affe. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für GSTM1 Antikörper (ABIN969180)

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GSTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Klon: 1H4A4

Produktdetails anti-GSTM1 Antikörper

Verwendungszweck: GSTM1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human GSTM1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-GSTM1 Antikörper (ABIN969180)

Navarro, Peterson, Chen, Makar, Schwarz, King, Li, Li, Kestin, Lampe: "Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial." in: Cancer prevention research (Philadelphia, Pa.), Vol. 2, Issue 4, pp. 345-52, (2009) (PubMed).

Details zu GSTM1

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Andere Bezeichnung: GSTM1

Hintergrund: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Molekulargewicht: 26 kDa

Gen-ID: 2944

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity