FGF2 Antikörper

Produktnummer ABIN969137

Der Maus Monoklonal Anti-FGF2-Antikörper wurde für ELISA und IHC validiert. Er ist geeignet, FGF2 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für FGF2 Antikörper (ABIN969137)

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FGF2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Klon: 2H5G2C11

Produktdetails anti-FGF2 Antikörper

Verwendungszweck: FGF2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of FGF2 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-FGF2 Antikörper (ABIN969137)

Kim, Shin, Choi, Kim, Ahn, Lee, Park, Kim, Mok, Nam: "A preliminary results of a randomized trial comparing monthly 5-flourouracil and cisplatin to weekly cisplatin alone combined with concurrent radiotherapy for locally advanced cervical cancer." in: Cancer research and treatment : official journal of Korean Cancer Association, Vol. 37, Issue 1, pp. 37-43, (2009) (PubMed).

Romanov, James, Sherrington, Pettitt: "Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia." in: Oncogene, Vol. 24, Issue 45, pp. 6855-60, (2005) (PubMed).

Webber, Chen, Hehr, Johnston, McFarlane: "Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance." in: Molecular and cellular neurosciences, Vol. 30, Issue 1, pp. 37-47, (2005) (PubMed).

Details zu FGF2

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Andere Bezeichnung: FGF2

Hintergrund: FGF2 is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF2 is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of anguogenesis. Due to its basic pH , the factor is named FGF-2 (basic FGF, bFGF).Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).

Gen-ID: 2247

UniProt: P09038

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteine