Dieses Maus Monoklonal-Antikörper erkennt spezifisch Fibrinogen beta Chain in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Koch, Hoppmann, Biele, Mueller, Schömig, Kastrati: "Fibrinogen genes and myocardial infarction: a haplotype analysis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 4, pp. 758-63, (2008) (PubMed).
Vu, Bolton-Maggs, Parr, Morris, de Moerloose, Neerman-Arbez: "Congenital afibrinogenemia: identification and expression of a missense mutation in FGB impairing fibrinogen secretion." in: Blood, Vol. 102, Issue 13, pp. 4413-5, (2003) (PubMed).
Target
Fibrinogen beta Chain (FGB)
Andere Bezeichnung
FGB
Hintergrund
Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.It is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.