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ErbB2/Her2 Antikörper (AA 750-987)

Dieses Anti-ErbB2/Her2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ErbB2/Her2 in WB, IHC, ELISA und FACS. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN969111

Kurzübersicht für ErbB2/Her2 Antikörper (AA 750-987) (ABIN969111)

Target

Alle ErbB2/Her2 Antikörper anzeigen
ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität

  • 457
  • 129
  • 122
  • 33
  • 8
  • 5
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 301
  • 172
  • 10
  • 6
  • 3
  • 2
  • 2
  • 1
Maus

Klonalität

  • 295
  • 197
  • 3
Monoklonal

Konjugat

  • 304
  • 25
  • 22
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 8
  • 7
  • 7
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation

  • 316
  • 140
  • 125
  • 110
  • 102
  • 93
  • 80
  • 75
  • 61
  • 54
  • 47
  • 30
  • 12
  • 9
  • 8
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Klon

6C2
  • Bindungsspezifität

    • 32
    • 30
    • 26
    • 25
    • 25
    • 24
    • 17
    • 17
    • 15
    • 13
    • 13
    • 10
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    AA 750-987

    Verwendungszweck

    ERBB2 Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of human ERBB2(aa750-987) expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Yamauchi, Stearns, Hayes: "When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive factor in breast cancer." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 8, pp. 2334-56, (2001) (PubMed).

  • Target

    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

    Andere Bezeichnung

    ERBB2

    Hintergrund

    ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

    Molekulargewicht

    180 kDa

    UniProt

    P04626

    Pathways

    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
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