DLK1 Antikörper

Produktnummer ABIN969086

Der Maus Monoklonal Anti-DLK1-Antikörper wurde für ELISA, FACS und ICC validiert. Er ist geeignet, DLK1 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für DLK1 Antikörper (ABIN969086)

Target: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DLK1 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 3A10

Produktdetails anti-DLK1 Antikörper

Verwendungszweck: DLK1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human DLK1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-DLK1 Antikörper (ABIN969086)

Espina, Méndez-Vidal, Moreno-Mateos, Sáez, Romero-Franco, Japón, Pintor-Toro: "Induction of Dlk1 by PTTG1 inhibits adipocyte differentiation and correlates with malignant transformation." in: Molecular biology of the cell, Vol. 20, Issue 14, pp. 3353-62, (2009) (PubMed).

Katrincsakova, Takeda, Urbankova, Michaux, Jarosova, Vandenberghe, Georges, Charlier, Wlodarska: "Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies." in: Epigenetics, Vol. 4, Issue 7, pp. 469-75, (2009) (PubMed).

Details zu DLK1

Target: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Andere Bezeichnung: DLK1

Hintergrund: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes, it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance, this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

Molekulargewicht: 41 kDa

Gen-ID: 8788

UniProt: P80370