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DDR1 Antikörper (AA 602-681)

DDR1 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 2G4E12 unconjugated
Produktnummer ABIN969082
  • Target Alle DDR1 Antikörper anzeigen
    DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
    Bindungsspezifität
    • 20
    • 15
    • 10
    • 7
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 602-681
    Reaktivität
    • 89
    • 43
    • 43
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Human
    Wirt
    • 94
    • 10
    Maus
    Klonalität
    • 93
    • 10
    • 1
    Monoklonal
    Konjugat
    • 50
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser DDR1 Antikörper ist unkonjugiert
    Applikation
    • 81
    • 42
    • 26
    • 26
    • 24
    • 14
    • 12
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of DDR1 (aa602-681) expressed in E. coli.
    Klon
    2G4E12
    Isotyp
    IgG1
    Top Product
    Discover our top product DDR1 Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Mohan, Mohan, Wilson: "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea." in: Experimental eye research, Vol. 72, Issue 1, pp. 87-92, (2001) (PubMed).

    Foehr, Tatavos, Tanabe, Raffioni, Goetz, Dimarco, De Luca, Bradshaw: "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 14, Issue 7, pp. 973-81, (2000) (PubMed).

  • Target
    DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
    Andere Bezeichnung
    DDR1 (DDR1 Produkte)
    Synonyme
    CG11573 antikoerper, CG13984 antikoerper, CG13985 antikoerper, CG33531 antikoerper, CG9488 antikoerper, CG9490 antikoerper, CT33540 antikoerper, DDR antikoerper, Dmel\\CG33531 antikoerper, Dmel_CG13984 antikoerper, 6030432F18 antikoerper, AI323681 antikoerper, CD167a antikoerper, Cak antikoerper, Nep antikoerper, PTK3A antikoerper, CAK antikoerper, CD167 antikoerper, EDDR1 antikoerper, HGK2 antikoerper, MCK10 antikoerper, NEP antikoerper, NTRK4 antikoerper, PTK3 antikoerper, RTK6 antikoerper, TRKE antikoerper, Drd1 antikoerper, PTK3D antikoerper, Discoidin domain receptor antikoerper, discoidin domain receptor family, member 1 antikoerper, discoidin domain receptor tyrosine kinase 1 antikoerper, Ddr antikoerper, Ddr1 antikoerper, DDR1 antikoerper
    Hintergrund

    Description: DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

    Aliases: CAK, DDR, NEP, PTK3, RTK6, TRKE, CD167

    Gen-ID
    780
    HGNC
    780
    Pathways
    RTK Signalweg, Smooth Muscle Cell Migration
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