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CD80 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD80 in ELISA, IHC und ICC. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN969028

Kurzübersicht für CD80 Antikörper (ABIN969028)

Target

Alle CD80 Antikörper anzeigen
CD80

Reaktivität

  • 157
  • 110
  • 46
  • 8
  • 6
  • 6
  • 1
  • 1
  • 1
Human

Wirt

  • 98
  • 80
  • 22
  • 21
  • 18
  • 2
  • 1
Maus

Klonalität

  • 158
  • 81
  • 2
Monoklonal

Konjugat

  • 99
  • 22
  • 19
  • 16
  • 12
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD80 Antikörper ist unkonjugiert

Applikation

  • 144
  • 96
  • 73
  • 39
  • 39
  • 26
  • 14
  • 13
  • 13
  • 13
  • 11
  • 10
  • 8
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon

2A2
  • Verwendungszweck

    CD80 Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of CD80 expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, (2008) (PubMed).

    Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, (2007) (PubMed).

  • Target

    CD80

    Andere Bezeichnung

    CD80

    Hintergrund

    The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.

    Molekulargewicht

    55 kDa

    Gen-ID

    941

    UniProt

    P33681

    Pathways

    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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