ARNTL
Reaktivität: Human
ELISA, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA: 1/10000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Yosifova, Mushiroda, Stoianov, Vazharova, Dimova, Karachanak, Zaharieva, Milanova, Madjirova, Gerdjikov, Tolev, Velkova, Kirov, Owen, ODonovan, Toncheva, Nakamura: "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population." in: Journal of affective disorders, Vol. 117, Issue 1-2, pp. 87-97, (2009) (PubMed).
Lee, Lee, Lee, Park, Kang, Chung, Lee, Kim: "Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 6056-65, (2008) (PubMed).
Motzkus, Loumi, Cadenas, Vinson, Forssmann, Maronde: "Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways." in: Chronobiology international, Vol. 24, Issue 5, pp. 783-92, (2007) (PubMed).
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.