TSG101 Antikörper (AA 229-319)

Produktnummer ABIN968912

Der Maus Monoklonal Anti-TSG101-Antikörper wurde für WB validiert. Er ist geeignet, TSG101 in Proben von Human, Maus, Ratte und Hund zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für TSG101 Antikörper (AA 229-319) (ABIN968912)

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TSG101 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 51-TSG101

Produktdetails anti-TSG101 Antikörper

Bindungsspezifität: AA 229-319

Kreuzreaktivität: Maus, Ratte (Rattus), Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human TSG101 aa. 229-319

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968586, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-TSG101 Antikörper (ABIN968912)

Li, Liao, Ruland, Mak, Cohen: "A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1619-24, (2001) (PubMed).

Zhong, Chen, Chen, Chen, Lee: "Identification of cellular TSG101 protein in multiple human breast cancer cell lines." in: Cancer research, Vol. 57, Issue 19, pp. 4225-8, (1997) (PubMed).

Li, Cohen: "Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells." in: Cell, Vol. 85, Issue 3, pp. 319-29, (1996) (PubMed).

Details zu TSG101

Target: TSG101 (Tumor Susceptibility Gene 101 (TSG101))

Andere Bezeichnung: TSG101

Hintergrund: Tumor Susceptibility Gene 101 (TSG101) was identified in a random mutagenesis screen for potential tumor suppressors in NIH 3T3 cells. Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. Though the function of TSG101 is not clearly understood, its protein structure includes motifs involved in transcription regulation, and TSG101 has been shown to modulate the activation of steroid hormone receptors. In addition, TSG101 may have a role in regulating ubiquination. The N-terminal region of TSG101 contains a domain that resembles the catalytically active region of ubiquitin conjugases. However, TSG101 lacks an active-site cysteine crucial to the function of these conjugases. Interestingly, TSG101 interferes with MDM2 ubiquination leading to a decrease in MDM2 decay and down-regulation of p53 protein. Thus, TSG101 may function as a dominant-negative inhibitor of ubiquination in pathways where protein expression is tightly regulated.
Synonyms: Tumor Susceptibility Gene 101

Molekulargewicht: 46 kDa